ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Matrix metalloproteinase-7 regulates cleavage of pro-nerve growth factor and is neuroprotective following kainic acid-induced seizures.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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39 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Association of Brain-derived Neurotrophic Factor Polymorphisms With Alcohol Use Disorder: An Updated Meta-Analysis of Genetic Association Studies.Brain and behavior · 2025Pooled it
- Pentylenetetrazole kindling impairs place recognition memory associated with suppressing proBDNF-mediated neural information flows at the hippocampal CA3-CA1 synapses.Frontiers in pharmacology · 2026Article
- Extracellular matrix and perineuronal nets in neural plasticity, memory, and epileptogenesis.Frontiers in molecular neuroscience · 2026Review
- The Intricate Relationship of Trk Receptors in Brain Diseases and Disorders.Molecular neurobiology · 2025Review
- ProNGF elicits retrograde axonal degeneration of basal forebrain neurons through p75Science signaling · 2024Article
- Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the hippocampus of lithium-pilocarpine-induced acute epileptic rats.Molecular biology reports · 2022Article
- Suppression of HIV-associated Macrophage Activation by a p75 Neurotrophin Receptor Ligand.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2022Article
- Piperine Provides Neuroprotection against Kainic Acid-Induced Neurotoxicity via Maintaining NGF Signalling Pathway.Molecules (Basel, Switzerland) · 2022Article
- Imbalance of nerve growth factor metabolism in aging women with overactive bladder syndrome.World journal of urology · 2021Article
- Production and activity of matrix metalloproteinases during liver fibrosis progression of chronic hepatitis C patients.World journal of hepatology · 2021Article
- c-Jun N-terminal Kinase Mediates Ligand-independent p75Neuroscience · 2021Article
- MMPs in learning and memory and neuropsychiatric disorders.Cellular and molecular life sciences : CMLS · 2019Review
- Pharmacological Manipulation of Trk, p75NTR, and NGF Balance Restores Memory Deficit in Global Ischemia/Reperfusion Model in Rats.Journal of molecular neuroscience : MN · 2019Article
- Loss of TrkB Signaling Due to Status Epilepticus Induces a proBDNF-Dependent Cell Death.Frontiers in cellular neuroscience · 2019Article
- Changes in vitreal protein profile and retina mRNAs in Reeler mice: NGF, IL33 and Müller cell activation.PloS one · 2019Article
- Blockade of p75 Neurotrophin Receptor Reverses Irritability and Anxiety-Related Behaviors in a Rat Model of Status EpilepticusIranian biomedical journal · 2018Article
- The pharmacological perturbation of brain zinc impairs BDNF-related signaling and the cognitive performances of young mice.Scientific reports · 2018Article
- Matrix Metalloproteinase-Mediated Blood-Brain Barrier Dysfunction in Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- PROneurotrophins and CONSequences.Molecular neurobiology · 2018Review
- ProBDNF/p75NTR/sortilin pathway is activated in peripheral blood of patients with alcohol dependence.Translational psychiatry · 2018Article
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2 authors at 1 institution in 3 countries.
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Abstract
The neurotrophin nerve growth factor (NGF) regulates neuronal growth, differentiation, and survival during development. However, the precursor of NGF, proNGF, is a potent apoptotic ligand for the p75 neurotrophin receptor (p75(NTR))-sortilin complex. The mechanisms that regulate cleavage of proNGF, therefore, are critical determinants of whether this factor promotes neuronal survival or death. In this study, we demonstrate that, following kainic acid-induced seizures, the proNGF processing enzyme matrix metalloproteinase 7 (MMP-7) and its inhibitor TIMP-1 (tissue inhibitor of matrix metalloproteinase 1) are regulated in a manner that prevents proneurotrophin cleavage and leads to increased proNGF in the extracellular milieu. Furthermore, we demonstrate both in vitro and in vivo that exogenous MMP-7 enhances proNGF cleavage and provides neuroprotection following kainic acid treatment. These data demonstrate that increased extracellular proNGF levels following seizures are stabilized by altered MMP-7 enzymatic activity, leading to increased neuronal death via activation of p75(NTR).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.