ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Tune it down to live it up? Rapid, nongenomic effects of cortisol on the human brain.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 50 citations in OpenAlex.
- Cortisol effects on flow-experience.Psychopharmacology · 2015Trial
- Intranasal insulin increases regional cerebral blood flow in the insular cortex in men independently of cortisol manipulation.Human brain mapping · 2014Trial
- Cardiometabolic risk mediates the association between perceived stress and learning and memory similarly among Hispanic/Latino and non-Hispanic White individuals.Journal of clinical and experimental neuropsychology · 2026Observational
- Subcallosal area 25: Its responsivity to the stress hormone cortisol and its opposing effects on appetitive motivation in marmosets.Neurobiology of stress · 2024Review
- Role of stress-related glucocorticoid changes in astrocyte-oligodendrocyte interactions that regulate myelin production and maintenance.Histology and histopathology · 2023Review
- Higher post-encoding cortisol benefits the selective consolidation of emotional aspects of memory.Neurobiology of learning and memory · 2021Article
- Rapid Action of Retinoic Acid on the Hypothalamic Pituitary Adrenal Axis.Frontiers in molecular neuroscience · 2019Article
- Acute Stress and Perceptual Load Consume the Same Attentional Resources: A Behavioral-ERP Study.PloS one · 2016Article
- Learning and memory under stress: implications for the classroom.NPJ science of learning · 2016Review
- Temporal dynamics of stress-induced alternations of intrinsic amygdala connectivity and neuroendocrine levels.PloS one · 2015Article
- Interoception and stress.Frontiers in psychology · 2015Review
- The hypothalamic-pituitary-adrenal-leptin axis and metabolic health: a systems approach to resilience, robustness and control.Interface focus · 2014Article
- Cortisol administration increases hippocampal activation to infant crying in males depending on childhood neglect.Human brain mapping · 2014Article
- Developmental mechanisms in the prodrome to psychosis.Development and psychopathology · 2013Review
- Sustained striatal activity predicts eudaimonic well-being and cortisol output.Psychological science · 2013Article
- Stress and neurodevelopmental processes in the emergence of psychosis.Neuroscience · 2013Review
- Optogenetic elevation of endogenous glucocorticoid level in larval zebrafish.Frontiers in neural circuits · 2013Article
- Time-dependent effects of cortisol on selective attention and emotional interference: a functional MRI study.Frontiers in integrative neuroscience · 2012Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The stress hormone cortisol acts on the brain, supporting adaptation and time-adjusted coping processes. Whereas previous research has focused on slow emerging, genomic effects of cortisol, we addressed the rapid, nongenomic cortisol effects on in vivo neuronal activity in humans. Three independent placebo-controlled studies in healthy men were conducted. We observed changes in CNS activity within 15 min after intravenous administration of a physiological dose of 4 mg of cortisol (hydrocortisone). Two of the studies demonstrated a rapid bilateral thalamic perfusion decrement using continuous arterial spin labeling. The third study revealed rapid, cortisol-induced changes in global signal strength and map dissimilarity of the electroencephalogram. Our data demonstrate that a physiological concentration of cortisol profoundly affects the functioning and perfusion of the human brain in vivo via a rapid, nongenomic mechanism. The changes in neuronal functioning suggest that cortisol acts on the thalamic relay of background as well as on task-specific sensory information, allowing focus and facilitation of adaptation to challenges.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.