ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Catenin-dependent cadherin function drives divisional segregation of spinal motor neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Spinal motor neuron development and metabolism are transcriptionally regulated by nuclear factor IA.Science advances · 2025Article
- Article
- Article
- CDH11 Regulates Adhesion and Transcellular Migration of Tongue Squamous Cell Carcinoma.OncoTargets and therapy · 2021Article
- Differential Spatiotemporal Expression of Type I and Type II Cadherins Associated With the Segmentation of the Central Nervous System and Formation of Brain Nuclei in the Developing Mouse.Frontiers in molecular neuroscience · 2021Article
- Distribution of Cadherin in the Parahippocampal Area of Developing Domestic Chicken Embryos.Experimental neurobiology · 2020Article
- Organization of motor pools depends on the combined function of N-cadherin and type II cadherins.Development (Cambridge, England) · 2019Article
- Motor neuron migration and positioning mechanisms: New roles for guidance cues.Seminars in cell & developmental biology · 2019Review
- EphrinB2 sharpens lateral motor column division in the developing spinal cord.Neural development · 2015Article
- Commissural axonal corridors instruct neuronal migration in the mouse spinal cord.Nature communications · 2015Article
- Polarity transitions during neurogenesis and germinal zone exit in the developing central nervous system.Frontiers in cellular neuroscience · 2015Review
- Central topography of cranial motor nuclei controlled by differential cadherin expression.Current biology : CB · 2014Article
- Reconstruction of phrenic neuron identity in embryonic stem cell-derived motor neurons.Development (Cambridge, England) · 2014Article
- Regulation of cadherin expression in nervous system development.Cell adhesion & migration · 2014Review
- Restricted expression of classic cadherins in the spinal cord of the chicken embryo.Frontiers in neuroanatomy · 2014Article
- Chicken embryo spinal cord slice culture protocol.Journal of visualized experiments : JoVE · 2013Article
- Epithelial mesenchymal transition from a natural gestational orchestration to a bizarre cancer disturbance.Cancer science · 2013Review
- β-Catenin gain of function in muscles impairs neuromuscular junction formation.Development (Cambridge, England) · 2012Article
- Foxp-mediated suppression of N-cadherin regulates neuroepithelial character and progenitor maintenance in the CNS.Neuron · 2012Article
- Cell adhesion and migration in the organization of spinal motor neurons.Cell adhesion & migrationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Motor neurons that control limb movements are organized as a neuronal nucleus in the developing ventral horn of the spinal cord called the lateral motor column. Neuronal migration segregates motor neurons into distinct lateral and medial divisions within the lateral motor column that project axons to dorsal or ventral limb targets, respectively. This migratory phase is followed by an aggregation phase whereby motor neurons within a division that project to the same muscle cluster together. These later phases of motor neuron organization depend on limb-regulated differential cadherin expression within motor neurons. Initially, all motor neurons display the same cadherin expression profile, which coincides with the migratory phase of motor neuron segregation. Here, we show that this early, pan-motor neuron cadherin function drives the divisional segregation of spinal motor neurons in the chicken embryo by controlling motor neuron migration. We manipulated pan-motor neuron cadherin function through dissociation of cadherin binding to their intracellular partners. We found that of the major intracellular transducers of cadherin signaling, γ-catenin and α-catenin predominate in the lateral motor column. In vivo manipulations that uncouple cadherin-catenin binding disrupt divisional segregation via deficits in motor neuron migration. Additionally, reduction of the expression of cadherin-7, a cadherin predominantly expressed in motor neurons only during their migration, also perturbs divisional segregation. Our results show that γ-catenin-dependent cadherin function is required for spinal motor neuron migration and divisional segregation and suggest a prolonged role for cadherin expression in all phases of motor neuron organization.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.