ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Prenatal immune activation interacts with genetic Nurr1 deficiency in the development of attentional impairments.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed, 129 citations in OpenAlex.
- High Mobility Group Box 1 Protein as a Biomarker in Adult Attention Deficit Hyperactivity Disorder.Alpha psychiatry · 2025Article
- Continuous oral olanzapine or clozapine treatment initiated in adolescence has differential short- and long-term impacts on antipsychotic sensitivity than those initiated in adulthood.European journal of pharmacology · 2024Article
- Maternal Influenza and Offspring Neurodevelopment.Current issues in molecular biology · 2024Review
- Associations between blood leukocyte DNA methylation and sustained attention in mid-to-late childhood.Epigenomics · 2023Article
- Mechanisms of NURR1 Regulation: Consequences for Its Biological Activity and Involvement in Pathology.International journal of molecular sciences · 2023Review
- Interaction of genetic liability for attention deficit hyperactivity disorder (ADHD) and perinatal inflammation contributes to ADHD symptoms in children.Brain, behavior, & immunity - health · 2023Article
- Dopamine, Immunity, and Disease.Pharmacological reviews · 2023Review
- NURR1-deficient mice have age- and sex-specific behavioral phenotypes.Journal of neuroscience research · 2022Article
- Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer's disease mouse model.Journal of neuroinflammation · 2022Article
- Prenatal allergic inflammation in rats programs the developmental trajectory of dendritic spine patterning in brain regions associated with cognitive and social behavior.Brain, behavior, and immunity · 2022Article
- A comprehensive approach to modeling maternal immune activation in rodents.Frontiers in neuroscience · 2022Review
- Lack of Vesicular Zinc Does Not Affect the Behavioral Phenotype of Polyinosinic:Polycytidylic Acid-Induced Maternal Immune Activation Mice.Frontiers in behavioral neuroscience · 2022Article
- Maternal Immune Activation during Pregnancy Alters Postnatal Brain Growth and Cognitive Development in Nonhuman Primate Offspring.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Review
- Maternal allergic inflammation in rats impacts the offspring perinatal neuroimmune milieu and the development of social play, locomotor behavior, and cognitive flexibility.Brain, behavior, and immunity · 2021Article
- In utero immune programming of autism spectrum disorder (ASD).Human immunology · 2021Article
- Increased levels of midbrain immune-related transcripts in schizophrenia and in murine offspring after maternal immune activation.Molecular psychiatry · 2021Article
- NURR1 Alterations in Perinatal Stress: A First Step towards Late-Onset Diseases? A Narrative Review.Biomedicines · 2020Review
- The Role of Immune Factors in Shaping Fetal Neurodevelopment.Annual review of cell and developmental biology · 2020Review
- The Critical Role of Nurr1 as a Mediator and Therapeutic Target in Alzheimer's Disease-related Pathogenesis.Aging and disease · 2020Review
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prenatal exposure to infection has been linked to increased risk of neurodevelopmental brain disorders, and recent evidence implicates altered dopaminergic development in this association. However, since the relative risk size of prenatal infection appears relatively small with respect to long-term neuropsychiatric outcomes, it is likely that this prenatal insult interacts with other factors in shaping the risk of postnatal brain dysfunctions. In the present study, we show that the neuropathological consequences of prenatal viral-like immune activation are exacerbated in offspring with genetic predisposition to dopaminergic abnormalities induced by mutations in Nurr1, a transcription factor highly essential for normal dopaminergic development. We combined a mouse model of heterozygous genetic deletion of Nurr1 with a model of prenatal immune challenge by the viral mimetic poly(I:C) (polyriboinosinic polyribocytidilic acid). In our gene-environment interaction model, we demonstrate that the combination of the genetic and environmental factors not only exerts additive effects on locomotor hyperactivity and sensorimotor gating deficits, but further produces synergistic effects in the development of impaired attentional shifting and sustained attention. We further demonstrate that the combination of the two factors is necessary to trigger maldevelopment of prefrontal cortical and ventral striatal dopamine systems. Our findings provide evidence for specific gene-environment interactions in the emergence of enduring attentional impairments and neuronal abnormalities pertinent to dopamine-associated brain disorders such as schizophrenia and attention deficit/hyperactivity disorder, and further emphasize a critical role of abnormal dopaminergic development in these etiopathological processes.
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