ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Genetic analysis of DSCAM's role as a Netrin-1 receptor in vertebrates.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 43 citations in OpenAlex.
- Future Directions for Studying the Potential of Mammalian Dscam in Autism Spectrum Disorder and Alzheimer's Disease: Insights from Dose Sensitivity.Molecular neurobiology · 2025Review
- Exploring perspectives of Dscam for cognitive deficits: a review of multifunction for regulating neural wiring in homeostasis.Frontiers in molecular neuroscience · 2025Review
- Slit-Robo signaling supports motor neuron avoidance of the spinal cord midline through DCC antagonism and other mechanisms.Frontiers in cell and developmental biology · 2025Article
- Insights from the neural guidance factor Netrin-1 into neurodegeneration and other diseases.Frontiers in molecular neuroscience · 2024Review
- Role of DSCAM in the Development of Neural Control of Movement and Locomotion.International journal of molecular sciences · 2021Review
- Commissural axon guidance in the developing spinal cord: from Cajal to the present day.Neural development · 2019Review
- DSCAM differentially modulates pre- and postsynaptic structural and functional central connectivity during visual system wiring.Neural development · 2018Article
- Revisiting Netrin-1: One Who Guides (Axons).Frontiers in cellular neuroscience · 2018Review
- Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Developmental role of DSCAM in spinal locomotor circuits.Journal of neurophysiology · 2017Review
- Recurrent DCC gene losses during bird evolution.Scientific reports · 2017Article
- DSCAM promotes axon fasciculation and growth in the developing optic pathway.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Dscam1 Forms a Complex with Robo1 and the N-Terminal Fragment of Slit to Promote the Growth of Longitudinal Axons.PLoS biology · 2016Article
- Overexpressed Down Syndrome Cell Adhesion Molecule (DSCAM) Deregulates P21-Activated Kinase (PAK) Activity in an In Vitro Neuronal Model of Down Syndrome: Consequences on Cell Process Formation and Extension.Neurotoxicity research · 2016Article
- NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord.eLife · 2016Article
- Role of DSCAM in the development of the spinal locomotor and sensorimotor circuits.Journal of neurophysiology · 2016Article
- Motor hypertonia and lack of locomotor coordination in mutant mice lacking DSCAM.Journal of neurophysiology · 2016Article
- Analysis of Expression Pattern and Genetic Deletion of Netrin5 in the Developing Mouse.Frontiers in molecular neuroscience · 2016Article
- Synergistic integration of Netrin and ephrin axon guidance signals by spinal motor neurons.eLife · 2015Article
- Netrin1-DCC-Mediated Attraction Guides Post-Crossing Commissural Axons in the Hindbrain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Down syndrome cell adhesion molecule (DSCAM) has mainly been characterized for its function as an adhesion molecule in axon growth and in self-recognition between dendrites of the same neuron. Recently, it has been shown that DSCAM can bind to Netrin-1 and that downregulation of DSCAM expression by siRNAs in chick and rodent spinal cords leads to impaired growth and turning response of commissural axons to Netrin-1. To investigate the effect of complete genetic ablation of DSCAM on Netrin-1-induced axon guidance, we analyzed spinal commissural neurons in DSCAM-null mice and found that they extend axons that reach and cross the floor plate and express apparently normal levels of the Netrin receptors DCC (deleted in colorectal carcinoma) and Neogenin. In vitro, commissural neurons in dorsal spinal cord explants of DSCAM-null embryos show normal outgrowth in response to Netrin-1. We therefore conclude that DSCAM is not required for Netrin-induced commissural axon outgrowth and guidance in mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.