ArticleClinical and vaccine immunology : CVI2012
Evaluation of gamma interferon (IFN-γ)-induced protein 10 responses for detection of cattle infected with Mycobacterium bovis: comparisons to IFN-γ responses.
Article in Clinical and vaccine immunology : CVI, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Exploring specific biomarkers in blood forFrontiers in microbiology · 2026Article
- Development and characterization of monoclonal antibodies specific for bovine IP-10.Veterinary research · 2025Article
- Buffalo Immune Competence Under Infectious and Non-Infectious Stressors.Animals : an open access journal from MDPI · 2025Review
- Evaluation of the performance of the IFN-γ release assay in bovine tuberculosis free herds from five European countries.Veterinary research · 2023Article
- Development of lateral flow assays to detect host proteins in cattle for improved diagnosis of bovine tuberculosis.Frontiers in veterinary science · 2023Article
- Cell-Mediated Immunological Biomarkers and Their Diagnostic Application in Livestock and Wildlife Infected WithFrontiers in immunology · 2021Review
- Immune response biomarkers in human and veterinary research.Comparative immunology, microbiology and infectious diseases · 2018Review
- TB Control in Humans and Animals in South Africa: A Perspective on Problems and Successes.Frontiers in veterinary science · 2018Article
- Limitations of Using IL-17A and IFN-γ-Induced Protein 10 to Detect Bovine Tuberculosis.Frontiers in veterinary science · 2018Article
- Positive Correlation between IP-10 and IFN-BioMed research international · 2017Article
- Interleukin-17A as a Biomarker for Bovine Tuberculosis.Clinical and vaccine immunology : CVI · 2016Article
- Antigen-Specific IP-10 Release Is a Sensitive Biomarker of Mycobacterium bovis Infection in Cattle.PloS one · 2016Article
- Milk yield and reproductive performance of Holstein cows testing positive for bovine tuberculosis.Tropical animal health and production · 2015Article
- IP-10 Is a Sensitive Biomarker of Antigen Recognition in Whole-Blood Stimulation Assays Used for the Diagnosis of Mycobacterium bovis Infection in African Buffaloes (Syncerus caffer).Clinical and vaccine immunology : CVI · 2015Article
- Mannosylated lipoarabinomannan in serum as a biomarker candidate for subclinical bovine tuberculosis.BMC research notes · 2014Article
- Evaluation of ethanol vortex ELISA for detection of bovine tuberculosis in cattle and deer.BMC veterinary research · 2014Article
- Circulating Mycobacterium bovis peptides and host response proteins as biomarkers for unambiguous detection of subclinical infection.Journal of clinical microbiology · 2014Article
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Authors and funding
9 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gamma interferon (IFN-γ)-induced protein 10 (IP-10) has recently shown promise as a diagnostic biomarker of Mycobacterium tuberculosis infection of humans. The aim of the current study was to compare IP-10 and IFN-γ responses upon Mycobacterium bovis infection in cattle by using archived samples from two aerosol inoculation studies. In the first study (10(4) CFU M. bovis by aerosol, n = 7), M. bovis purified protein derivative (PPDb)-specific IP-10 and IFN-γ gene expression was detected as early as 29 days after challenge. PPDb-specific IP-10 and IFN-γ mRNA responses followed a similar pattern of expression over the course of this study and were highly correlated (r = 0.87). In the second study (10(5) CFU M. bovis by aerosol, n = 5), IP-10 and IFN-γ (protein) responses to mycobacterial antigens were compared following challenge. IFN-γ responses to mycobacterial antigens were detected at 29 days after challenge and were sustained during the remainder of the study. IFN-γ responses to mycobacterial antigens exceeded corresponding responses in nonstimulated cultures. IP-10 responses to mycobacterial antigens exceeded preinfection responses at 7, 29, and 63 days after challenge. In contrast to IFN-γ responses, IP-10 responses to mycobacterial antigens generally did not exceed the respective responses in nonstimulated cultures. IP-10 responses to medium alone and to mycobacterial antigens followed a similar pattern of response. Correlations between IP-10 and IFN-γ (protein) responses were modest (r ≈ 0.50 to 0.65). Taken together, these findings do not support the use of IP-10 protein as a biomarker for bovine tuberculosis using the current testing protocol and reagents; however, mRNA-based assays may be considered for further analysis.
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