Evidence map›Paper›PMID 22237889›Full record

ArticleClinical and vaccine immunology : CVI2012

Postvaccination increase in serotype 19A pneumococcal disease in Norway is driven by expansion of penicillin-susceptible strains of the ST199 complex.

Didrik F Vestrheim, Martin Steinbakk, Ingeborg S Aaberge, Dominique A Caugant

Open access · diamondAbstract read
In one paragraph

Article in Clinical and vaccine immunology : CVI, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

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  5. The Emergence of InvasiveFrontiers in microbiology · 2021
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  6. Disruption of theVaccines · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Didrik F VestrheimDepartment of Bacteriology and Immunology, Norwegian Institute of Public Health, Oslo, Norway. didrik.frimann.vestrheim@fhi.no
Martin Steinbakk
Ingeborg S Aaberge
Dominique A Caugant
Norwegian Institute of Public Health · NOUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serotype replacement in invasive pneumococcal disease has been observed after widespread use of the 7-valent pneumococcal conjugate vaccine (PCV7). Replacement is dominated by penicillin-nonsusceptible serotype 19A in several countries. Antibiotic selection pressure has been proposed to interact with immunization, leading to rapid replacement. In Norway, where prescription of antibiotics is limited, post-PCV7 replacement by serotype 19A is dominated by penicillin-susceptible clones. Hence, serotype 19A replacement occurs, although it is not driven by antibiotic selection pressure.

Indexed as

Anti-Bacterial AgentsChildChild, PreschoolHeptavalent Pneumococcal Conjugate VaccineHumansMicrobial Sensitivity TestsNorwayPenicillinsPneumococcal InfectionsPneumococcal VaccinesSerotypingStreptococcus pneumoniaeAnti-Bacterial AgentsHeptavalent Pneumococcal Conjugate VaccinePenicillinsPneumococcal Vaccines

Identifiers

PMID22237889
PMCPMC3294600
OpenAlexW2071452243

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.