ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2012
Precision of ¹⁸F-fluoride PET skeletal kinetic studies in the assessment of bone metabolism.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 26 citations in OpenAlex.
- The emerging role of ¹⁸F-NaF PET/CT in osteoporosis: an emphasis on its application for the evaluation and management of lumbar spine osteoporosis.EJNMMI research · 2026Review
- Mixed uremic osteodystrophy: an ill-described common bone pathology in patients with chronic kidney disease.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Review
- Management of fracture risk in CKD-traditional and novel approaches.Clinical kidney journal · 2023Review
- Effects of dynamic [Frontiers in nuclear medicine · 2023Article
- Association between bone mineral metabolism and vascular calcification in end-stage renal disease.BMC nephrology · 2022Article
- Bone Histomorphometry andCalcified tissue international · 2021Article
- Assessment of quantitative [Osteoarthritis and cartilage · 2021Article
- Reinventing Molecular Imaging with Total-Body PET, Part II: Clinical Applications.PET clinics · 2020Review
- Assessment of acute bone loading in humans using [European journal of nuclear medicine and molecular imaging · 2019Article
- Kinetic [18F]-Fluoride of the Knee in Normal Volunteers.Clinical nuclear medicine · 2019Article
- MRI assessment of bone structure and microarchitecture.Journal of magnetic resonance imaging : JMRI · 2017Review
- Technologies for assessment of bone reflecting bone strength and bone mineral density in elderly women: an update.Women's health (London, England) · 2016Article
- Differentiation of metastatic vs degenerative joint disease using semi-quantitative analysis with (18)F-NaF PET/CT in castrate resistant prostate cancer patients.American journal of nuclear medicine and molecular imaging · 2015Article
- Imaging of site specific bone turnover in osteoporosis using positron emission tomography.Current osteoporosis reports · 2014Review
- Factors Affecting Uptake of NaF-18 by the Normal Skeleton.Journal of clinical medicine research · 2014Article
- Article
- Time course of bone metabolism at the residual ridge beneath dentures observed using ¹⁸F-fluoride positron emission computerized-tomography/computed tomography (PET/CT).Annals of nuclear medicine · 2012Article
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5 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
unlabelledWe assessed the precision of lumbar spine (18)F-PET measurements based on 58 scans performed on 20 postmenopausal women. The percentage coefficient of variation (%CV) (95% confidence interval) was 9.2% (7.5-11.8) for standardised uptake values, 11.7% (9.5-14.9) for plasma clearance measurements using the Patlak method and 14.5% (11.7-18.5) for plasma clearance measurements using the Hawkins three-compartment model.
introduction(18)F-Fluoride positron emission tomography ((18)F-PET) is a non-invasive technique that allows the assessment of regional bone turnover in patients with metabolic bone disease. Knowledge of the precision errors of (18)F-PET measurements is important for planning the number of subjects required for research studies.
methodsTwenty osteoporotic postmenopausal women had (18)F-PET scans of the lumbar spine at 0, 6 and 12 months after stopping long-term bisphosphonate treatment. No significant changes in the PET measurements were seen over the 12-month period, and the data were deemed suitable for a precision study. Precision errors were evaluated for standardised uptake values (SUVs) and for the fluoride plasma clearance to bone mineral (K (i)) determined using the Patlak and Hawkins methods. Precision errors were expressed as the %CV and were calculated for the mean L1-L4 region and for individual vertebrae.
results%CV (95% confidence interval) for the L1-L4 region was 9.2% (7.5-11.8) for SUV, 11.7% (9.5-14.9) for K (i) measured using the Patlak method and 14.5% (11.7-18.5) for K (i) measured using the Hawkins method. There was no significant difference between precision errors obtained for the L1-L4 region and those obtained for a single vertebra.
conclusionsSUV measurements showed the smallest precision error followed by the Patlak method, while the Hawkins method gave the largest error. Measuring a smaller region of interest did not increase the precision error, suggesting that the factor determining the errors may be scanner calibration.
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