Evidence map›Paper›PMID 22237780›Full record

ArticleLeukemia2012

Mechanisms and consequences of the loss of PHLPP1 phosphatase in chronic lymphocytic leukemia (CLL).

M O'Hayre, M Niederst, J F Fecteau, V M Nguyen, T J Kipps, D Messmer, A C Newton, T M Handel

Open access · hybridAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. PHLPPing the Script: Emerging Roles of PHLPP Phosphatases in Cell Signaling.Annual review of pharmacology and toxicology · 2021
    Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

M O'Hayre
M Niederst
J F Fecteau
V M Nguyen
T J Kipps
D Messmer
A C Newton
T M Handel
University of California, San Diego · US

Funding

Tissue CoreP01CA081534 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KIPPS, THOMAS J · 2000 to 2016
$59.5M
GRADUATE TRAINING IN CELLULAR &MOLECULAR PHARMACOLOGYT32GM007752 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROWN, JOAN HELLER, HANDEL, TRACY M · 1985 to 2023
$13.5M
STRUCTURE OF MACROPHAGE CHEMOTACTIC ACTIVATING PROTEINSR01AI037113 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HANDEL, TRACY M · 1995 to 2015
$5.2M
Signal Termination by PHLPP, PH domain Leucine-rich repeat Protein PhosphataseR01GM067946 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NEWTON, ALEXANDRA C. · 2003 to 2014
$4.1M
Structure, Function and Regulation of Protein Kinase CR37GM043154 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NEWTON, ALEXANDRA C. · 2003 to 2012
$4.0M
STRUCTURE/FUNCTION AND REGULATION OF PROTEIN KINASE CR01GM043154 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NEWTON, ALEXANDRA C. · 1990 to 2016
$2.5M
NCI NIH HHS P01 CA081534NIAID NIH HHS R01 AI037113NIGMS NIH HHS R01 GM043154NIGMS NIH HHS R01 GM067946NIGMS NIH HHS R37 GM043154NIGMS NIH HHS T32 GM007752PHS HHS GM 43154-ACN
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DNA MethylationBlotting, WesternB-LymphocytesCase-Control StudiesHumansLeukemia, Lymphocytic, Chronic, B-CellMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Nuclear ProteinsPhosphoprotein PhosphatasesPhosphorylationPromoter Regions, GeneticProtein Kinase CProtein Kinase C betaProto-Oncogene Proteins c-aktReal-Time Polymerase Chain ReactionCXCR4 protein, humanMAPK1 protein, humanMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Nuclear ProteinsPHLPP1 protein, humanPhosphoprotein PhosphatasesProtein Kinase CProtein Kinase C betaProto-Oncogene Proteins c-aktReceptors, CXCR4RNA, Messenger

Identifiers

PMID22237780
PMCPMC3395972
OpenAlexW2005438787

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.