ReviewPediatric nephrology (Berlin, Germany)2012
Renal salt-wasting syndrome in children with intracranial disorders.
Review in Pediatric nephrology (Berlin, Germany), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- Dysnatremias in pediatric victims of the 2023 Türkiye-Syria earthquake.Pediatric nephrology (Berlin, Germany) · 2025Article
- Successful Management of Cerebral Salt-Wasting Syndrome in a Child With Epileptic Encephalopathy: A Case Report.Clinical case reports · 2025Article
- Which Intravenous Isotonic Fluid Offers Better Outcomes for Patients with a Brain Injury?Neurocritical care · 2025Review
- Metabolic insights and background from naturally affected pigs duringTranslational animal science · 2023Article
- Differential diagnosis between syndrome of inappropriate antidiuretic hormone secretion and cerebral/renal salt wasting syndrome in children over 1 year: proposal for a simple algorithm.Pediatric nephrology (Berlin, Germany) · 2022Review
- Distribution of plasma copeptin levels and influence of obesity in children and adolescents.European journal of pediatrics · 2021Article
- A Case of Kawasaki Disease Complicated With Cerebral Salt-Wasting Syndrome.Frontiers in pediatrics · 2020Article
- Article
- Na(+), K(+), Cl(-), acid-base or H2O homeostasis in children with urinary tract infections: a narrative review.Pediatric nephrology (Berlin, Germany) · 2016Review
- Cerebral salt wasting syndrome due to tuberculous meningitis; a case report.Journal of renal injury prevention · 2016Article
- Impact of perioperative hyponatremia in children: A narrative review.World journal of critical care medicine · 2014Review
- Hyponatremia in children with tuberculous meningitis: A hospital-based cohort study.Journal of pediatric neurosciencesArticle
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6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypotonic hyponatremia, a serious and recognized complication of any intracranial disorder, results from extra-cellular fluid volume depletion, inappropriate anti-diuresis or renal salt-wasting. The putative mechanisms by which intracranial disorders might lead to renal salt-wasting are either a disrupted neural input to the kidney or the elaboration of a circulating natriuretic factor. The key to diagnosis of renal salt-wasting lies in the assessment of extra-cellular volume status: the central venous pressure is currently considered the yardstick for measuring fluid volume status in subjects with intracranial disorders and hyponatremia. Approximately 110 cases have been reported so far in subjects ≤18 years of age (male: 63%; female: 37%): intracranial surgery, meningo-encephalitis (most frequently tuberculous) or head injury were the most common underlying disorders. Volume and sodium repletion are the goals of treatment, and this can be performed using some combination of isotonic saline, hypertonic saline, and mineralocorticoids (fludrocortisone). It is worthy of a mention, however, that some authorities contend that cerebral salt wasting syndrome does not exist, since this diagnosis requires evidence of a reduced arterial blood volume, a concept but not a measurable variable.
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