ArticleThe Journal of comparative neurology2012
Synaptic plasticity in the medial superior olive of hearing, deaf, and cochlear-implanted cats.
Article in The Journal of comparative neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Effect of Sound Amplification on Central Auditory Plasticity: Endbulb of Held as a Substrate.Brain sciences · 2025Article
- Dissociated Representation of Binaural Cues in Single-Sided Deafness: Implications for Cochlear Implantation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Reweighting of Binaural Localization Cues in Bilateral Cochlear-Implant Listeners.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Microsecond interaural time difference discrimination restored by cochlear implants after neonatal deafness.eLife · 2021Article
- Regulation of auditory plasticity during critical periods and following hearing loss.Hearing research · 2020Review
- Relationship between Metabolomics Profile of Perilymph in Cochlear-Implanted Patients and Duration of Hearing Loss.Metabolites · 2019Article
- Auditory motion tracking ability of adults with normal hearing and with bilateral cochlear implants.The Journal of the Acoustical Society of America · 2019Article
- Neural ITD Sensitivity and Temporal Coding with Cochlear Implants in an Animal Model of Early-Onset Deafness.Journal of the Association for Research in Otolaryngology : JARO · 2019Article
- Impact of Auditory Experience on the Structural Plasticity of the AIS in the Mouse Brainstem Throughout the Lifespan.Frontiers in cellular neuroscience · 2019Article
- Improved Neural Coding of ITD with Bilateral Cochlear Implants by Introducing Short Inter-pulse Intervals.Journal of the Association for Research in Otolaryngology : JARO · 2018Article
- Article
- Binaural sensitivity in children who use bilateral cochlear implants.The Journal of the Acoustical Society of America · 2017Article
- Cortical Representation of Interaural Time Difference Is Impaired by Deafness in Development: Evidence from Children with Early Long-term Access to Sound through Bilateral Cochlear Implants Provided Simultaneously.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Binaural fusion and listening effort in children who use bilateral cochlear implants: a psychoacoustic and pupillometric study.PloS one · 2015Article
- Commentary: "Compensatory plasticity: time matters".Frontiers in neuroscience · 2015Article
- Central plasticity and dysfunction elicited by aural deprivation in the critical period.Frontiers in neural circuits · 2015Review
- Multisensory training improves auditory spatial processing following bilateral cochlear implantation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Functional and structural changes throughout the auditory system following congenital and early-onset deafness: implications for hearing restoration.Frontiers in systems neuroscience · 2013Review
- Chronic neurotrophin delivery promotes ectopic neurite growth from the spiral ganglion of deafened cochleae without compromising the spatial selectivity of cochlear implants.The Journal of comparative neurology · 2013Article
- Congenital and prolonged adult-onset deafness cause distinct degradations in neural ITD coding with bilateral cochlear implants.Journal of the Association for Research in Otolaryngology : JARO · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The medial superior olive (MSO) is a key auditory brainstem structure that receives binaural inputs and is implicated in processing interaural time disparities used for sound localization. The deaf white cat, a proven model of congenital deafness, was used to examine how deafness and cochlear implantation affected the synaptic organization at this binaural center in the ascending auditory pathway. The patterns of axosomatic and axodendritic organization were determined for principal neurons from the MSO of hearing, deaf, and deaf cats with cochlear implants. The nature of the synapses was evaluated through electron microscopy, ultrastructure analysis of the synaptic vesicles, and immunohistochemistry. The results show that the proportion of inhibitory axosomatic terminals was significantly smaller in deaf animals when compared with hearing animals. However, after a period of electrical stimulation via cochlear implants the proportion of inhibitory inputs resembled that of hearing animals. Additionally, the excitatory axodendritic boutons of hearing cats were found to be significantly larger than those of deaf cats. Boutons of stimulated cats were significantly larger than the boutons in deaf cats, although not as large as in the hearing cats, indicating a partial recovery of excitatory inputs to MSO dendrites after stimulation. These results exemplify dynamic plasticity in the auditory brainstem and reveal that electrical stimulation through cochlear implants has a restorative effect on synaptic organization in the MSO.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.