ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2012
Hyperthermia induces injury to the intestinal mucosa in the mouse: evidence for an oxidative stress mechanism.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 71 citations in OpenAlex.
- Trial
- The impact of exertional-heat stress on gastrointestinal integrity, gastrointestinal symptoms, systemic endotoxin and cytokine profile.European journal of applied physiology · 2018Trial
- Effects of probiotics supplementation on gastrointestinal permeability, inflammation and exercise performance in the heat.European journal of applied physiology · 2014Trial
- Extreme temperatures and the epithelial barrier theory.Seminars in immunopathology · 2026Review
- Investigating alterations associated with heat stress and the recovery of the intestinal barrier using IPEC-J2 as an intestinal epithelial porcine cell model.Scientific reports · 2026Article
- Association between heatwave exposure and rapid kidney function decline: a longitudinal cohort study from CHARLS.BMC public health · 2025Article
- Differential intestinal injury and unchanged systemic inflammatory responses to leg and whole-body passive hyperthermia in healthy humans.Experimental physiology · 2025Article
- Heat stroke with sepsis: A case report and review of the literature.The Journal of international medical research · 2025Review
- Regional Heterogeneity in Intestinal Epithelial Barrier Permeability and Mesenteric Perfusion After Thoracic Spinal Cord Injury.Digestive diseases and sciences · 2024Article
- Supplementation of vitamin E or a botanical extract as antioxidants to improve growth performance and health of growing pigs housed under thermoneutral or heat-stressed conditions.Journal of animal science and biotechnology · 2024Article
- Therapeutic effects of mitoquinol during an acute heat stress challenge in growing gilts.Journal of animal science · 2024Article
- Therapeutic effects of mitoquinol during an acute heat stress challenge in growing barrows.Journal of animal science · 2024Article
- Glutamine Supplementation: A Possible Strategy to Help Mitigate Health Risks of Heat-Related Illness.Journal of nutrition and metabolism · 2024Review
- Design of Antioxidant Nanoparticle, which Selectively Locates and Scavenges Reactive Oxygen Species in the Gastrointestinal Tract, Increasing The Running Time of Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Endothelial glycocalyx injury is involved in heatstroke-associated coagulopathy and protected by N-acetylcysteine.Frontiers in immunology · 2023Article
- Glutamine supplementation attenuates intestinal apoptosis by inducing heat shock protein 70 in heatstroke rats.World journal of emergency medicine · 2023Article
- The pathogenesis and therapeutic strategies of heat stroke-induced liver injury.Critical care (London, England) · 2022Review
- Influence of feeding Saccharomyces cerevisiae on the heat load responses of lactating dairy cows during summer.International journal of biometeorology · 2022Article
- Exertional heat stroke: pathophysiology and risk factors.BMJ medicine · 2022Review
- Heat Stress-Mediated Activation of Immune-Inflammatory Pathways.Antibiotics (Basel, Switzerland) · 2021Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Loss of the intestinal barrier is critical to the clinical course of heat illness, but the underlying mechanisms are still poorly understood. We tested the hypothesis that conditions characteristic of mild heatstroke in mice are associated with injury to the epithelial lining of the intestinal tract and comprise a critical component of barrier dysfunction. Anesthetized mice were gavaged with 4 kDa FITC-dextran (FD-4) and exposed to increasing core temperatures, briefly reaching 42.4°C, followed by 30 min recovery. Arterial samples were collected to measure FD-4 concentration in plasma (in vivo gastrointestinal permeability). The small intestines were then removed to measure histological evidence of injury. Hyperthermia resulted in a ≈2.5-fold elevation in plasma FD-4 and was always associated with significant histological evidence of injury to the epithelial lining compared with matched controls, particularly in the duodenum. When isolated intestinal segments from control animals were exposed to ≥41.5°C, marked increases in permeability were observed within 60 min. These changes were associated with release of lactate dehydrogenase, evidence of protein oxidation via carbonyl formation and histological damage. Coincubation with N-acetylcysteine protected in vitro permeability during hyperthermia and reduced histological damage and protein oxidation. Chelation of intracellular Ca(2+) to block tight junction opening during 41.5°C exposure failed to reduce the permeability of in vitro segments. The results demonstrate that hyperthermia exposure in mouse intestine, at temperatures at or below those necessary to induce mild heatstroke, cause rapid and substantial injury to the intestinal lining that may be attributed, in part, to oxidative stress.
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