ArticleJournal of cancer research and clinical oncology2012
Comparison of clinicopathological characteristics and prognoses between bilateral and unilateral breast cancer.
Article in Journal of cancer research and clinical oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- The prognostic comparison among unilateral, bilateral, synchronous bilateral, and metachronous bilateral breast cancer: A meta-analysis of studies from recent decade (2008-2018).Cancer medicine · 2019Pooled it
- Clinicopathological characteristics and potential impact of previous treatment history in metachronous contralateral breast cancer: Insights from a real-world retrospective study.Oncology letters · 2026Article
- Illuminating Bilateral Breast Cancer: A Multicenter Experience and Clinical Observations.Medicina (Kaunas, Lithuania) · 2025Article
- Comparison of survival between unilateral and bilateral breast cancers using propensity score matching: a retrospective single-center analysis.Breast cancer research and treatment · 2025Article
- A comparative clinicopathological and survival analysis of synchronous bilateral breast cancers.Histology and histopathology · 2022Article
- Clinicopathological features and prognosis of bilateral breast cancer: a single-center cohort study based on Chinese data.Annals of translational medicine · 2022Article
- Bilateral breast cancer in China: A 10-year single-center retrospective study (2006-2016).Cancer medicine · 2021Article
- Comparative Analysis of Outcomes and Clinicopathological Characteristics of Synchronous and Metachronous Contralateral Breast Cancer: A Study of the SEER Database.Journal of breast cancer · 2019Article
- Contralateral breast cancers: Independent cancers or metastases?International journal of cancer · 2018Article
- Comparison of the histopathology and prognosis of bilateral versus unilateral multifocal multicentric breast cancers.World journal of surgical oncology · 2014Article
- Bilateral Paget's Disease of the Breast-Case Report of Long-Time Misdiagnosed Tumors with Underlying Ductal Carcinomas and Review of the Literature.Case reports in dermatological medicine · 2014Article
- Article
- Are synchronous and metachronous bilateral breast cancers different? An immunohistochemical analysis aimed at intrinsic tumor phenotype.International journal of clinical and experimental pathology · 2014Article
- The prognosis of synchronous and metachronous bilateral breast cancer in Chinese patients.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
- The molecular and clinicopathologic characteristics of bilateral breast cancer.Scientific reports · 2013Article
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe clinical significance of bilateral breast cancer is unclear and its influence on prognosis is controversial. We compared the characteristics and prognosis of bilateral breast cancer and unilateral breast cancer.
methodsOur study included 4,183 patients with breast cancer who were treated at Sun Yat-sen University Cancer Center between January 1, 2000, and December 31, 2007. Bilateral breast cancer was categorized as synchronous (within 3 months) or metachronous (diagnosed after 3 months of first cancer). SPSS was used for data analysis.
results106 (2.5%) and 31 (0.7%) patients were diagnosed with metachronous and synchronous bilateral cancer. Women with bilateral cancer had more frequent postmenopause, HER-2 negativity, and advanced disease than in patients with unilateral cancer. Young age at diagnosis, invasive lobular carcinoma, ER/PR negativity, HER-2 positivity, radiation, large tumor size (T > 5 cm), and stage III disease of the first cancer were risk factors for contralateral cancer. The 5-year disease-free survival and overall survival rates were 76 and 83% for unilateral cancer, while 32 and 72% for bilateral cancer (P = 0.000 for both).
conclusionsBilateral cancer was associated with shorter disease-free survival and overall survival than unilateral cancer. The prognosis of metachronous bilateral cancer, especially those diagnosed within 2 years after the first cancer was significantly worse than synchronous bilateral cancer.
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