ReviewJournal of innate immunity2012
Immune response in the barrier epithelia: lessons from the fruit fly Drosophila melanogaster.
Review in Journal of innate immunity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 93 citations in OpenAlex.
- Tracheal terminal cells ofeLife · 2026Article
- TmKayak functions as an effector of Jun N-terminal kinase pathway to modulate immune responses in Tenebrio molitor.Scientific reports · 2026Article
- The Genetic Architecture of Venom Resistance: A Novel Approach to Target Identification and Coevolutionary Discovery.Molecular biology and evolution · 2026Article
- Identification ofFrontiers in immunology · 2026Review
- The Role of Gut Microbiota in Shaping Immune Responses in Tephritidae Fruit Fly and Prospective Implications for Management.Neotropical entomology · 2025Review
- Cross-talk between immunity and behavior: insights from entomopathogenic fungi and their insect hosts.FEMS microbiology reviews · 2024Review
- The humoral immune response of the lepidopteran model insect, silkwormCurrent research in insect science · 2024Review
- Peroxiredoxins Play an Important Role in the Regulation of Immunity and Aging inAntioxidants (Basel, Switzerland) · 2023Article
- Intestinal Immune Deficiency and Juvenile Hormone Signaling Mediate a Metabolic Trade-off in AdultMetabolites · 2023Article
- Article
- Drosophila caspases as guardians of host-microbe interactions.Cell death and differentiation · 2023Review
- Stilbenoid compounds inhibit NF-κB-mediated inflammatory responses in theFrontiers in immunology · 2023Article
- Evidence of a conserved mammalian immunosuppression mechanism inFrontiers in immunology · 2023Article
- Immunometabolic regulation during the presence of microorganisms and parasitoids in insects.Frontiers in immunology · 2023Review
- Immunological Roles ofInternational journal of molecular sciences · 2022Article
- M1-linked ubiquitination facilitates NF-κB activation and survival during sterile inflammation.The FEBS journal · 2022Article
- Excreted secreted products from the parasitic nematode Steinernema carpocapsae manipulate the Drosophila melanogaster immune response.Scientific reports · 2022Article
- Sensing microbial infections in the Drosophila melanogaster genetic model organism.Immunogenetics · 2022Review
- Co-option of immune effectors by the hormonal signalling system triggering metamorphosis in Drosophila melanogaster.PLoS genetics · 2021Article
- Genome-enabled insights into the biology of thrips as crop pests.BMC biology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The barrier epithelia of multicellular organisms frequently come into direct contact with microorganisms and thus need to fulfill the important task of preventing the penetration of pathogens that could cause systemic infections. A functional immune defence in the epithelial linings of the digestive, respiratory and reproductive organs as well as the epidermis/skin of animals is therefore of crucial importance for survival. Epithelial defence reactions are likely to be evolutionarily ancient, and the use of invertebrate animal models, such as insects and nematodes, has been crucial in unravelling the mechanisms underlying epithelial immunity. This review addresses basic questions of epithelial immunity in animals and humans. It focuses on recent developments in the understanding of the immune responses in the fruit fly Drosophila melanogaster and how the innate immune system acts locally in the epidermis and cuticle, tracheae, gut and genital organs. Both basal immune activities in epithelia that are constantly exposed to microbes as well as positive and negative regulation in response to pathogenic organisms are covered. Important immuno-physiological aspects of epithelial defence mechanisms are also discussed, such as wound healing, re-epithelialization and intestinal homeostasis.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.