ArticleEpidemiology (Cambridge, Mass.)2012
Air pollution and markers of coagulation, inflammation, and endothelial function: associations and epigene-environment interactions in an elderly cohort.
Article in Epidemiology (Cambridge, Mass.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02469428 (Epigenetic Effect Modifications With Ozone Exposure on Healthy Volunteers), which is not on this map. Cited by 161 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Epigenetic Effect Modifications With Ozone Exposure on Healthy Volunteers
Who cites it
161 citing papers in PubMed, 1 synthesis or guideline pooled it, 295 citations in OpenAlex.
- Health effects of ultrafine particles: a systematic literature review update of epidemiological evidence.International journal of public health · 2019Pooled it
- Interaction effects of temperature and ozone on lung function and markers of systemic inflammation, coagulation, and fibrinolysis: a crossover study of healthy young volunteers.Environmental health perspectives · 2015Trial
- Inhalation of ultrafine carbon particles alters heart rate and heart rate variability in people with type 2 diabetes.Particle and fibre toxicology · 2014Trial
- The impacts of short-term exposure to noise and traffic-related air pollution on heart rate variability in young healthy adults.Journal of exposure science & environmental epidemiologyTrial
- Saliva Spectral Signature and LINE-1 Methylation in Oral Cells: Impact of Air Pollution in São Paulo State Residents.Scientifica · 2026Article
- Article
- Air pollution and the number of daily visits of hypertension in northern china: a time-series analysis on generalized additive model.Scientific reports · 2025Article
- The Joint Effects of Exposure to Ambient Long-term Air Pollution and Short-term Heat on Epigenetic Aging in the Health and Retirement Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Multiphase Radical Chemical Processes Induced by Air Pollutants and the Associated Health Effects.Environment & health (Washington, D.C.) · 2025Review
- Ozone exposure and cardiovascular disease: A narrative review of epidemiology evidence and underlying mechanisms.Fundamental research · 2025Review
- Short-term air pollution and fracture admissions in Beijing.Frontiers in public health · 2025Article
- Fine particulate matter and intima media thickness: Role of endothelial function biomarkers.Environmental epidemiology (Philadelphia, Pa.) · 2024Article
- Article
- The Risk of the Aggravation of Diabetic Foot According to Air Quality Factors in the Republic of Korea: A Nationwide Population-Based Study.International journal of environmental research and public health · 2024Article
- Sex-specific associations between the environmental exposures and low-grade inflammation and increased blood pressure in young, healthy subjects.Scientific reports · 2024Article
- Long-term air pollution exposure is associated with higher incidence of ST-elevation myocardial infarction and in-hospital cardiogenic shock.Scientific reports · 2024Article
- Coarse Particulate Matter and Markers of Inflammation and Coagulation in the Multi-Ethnic Study of Atherosclerosis (MESA) Population: A Repeat Measures Analysis.Environmental health perspectives · 2024Article
- Exposure to PMEnvironmental geochemistry and health · 2024Article
- Association between ambient air pollution and outpatient visits of cardiovascular diseases in Zibo, China: a time series analysis.Frontiers in public health · 2024Article
- Review
101 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundPrevious studies suggest that air pollution is related to thrombosis, inflammation, and endothelial dysfunction. Mechanisms and sources of susceptibility are still unclear. One possibility is that these associations can be modified by DNA methylation states.
methodsWe conducted a cohort study with repeated measurements of fibrinogen, C-reactive protein, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in 704 elderly men participating in the Veterans Administration Normative Aging Study (2000-2009). We investigated short- and intermediate-term air pollution effects on these blood markers, and epigene-environment interactions by DNA methylation of Alu, LINE-1, tissue factor (F3), Toll-like receptor 2 (TLR-2), and ICAM-1.
resultsWe found effects of particle number, black carbon, nitrogen dioxide (NO(2)), and carbon monoxide (CO) on fibrinogen. Ozone was a predictor of C-reactive protein and ICAM-1. Particle number, black carbon, NO(2), CO, PM(2.5), and sulfates were associated with ICAM-1 and VCAM-1. An interquartile range increase in 24-hour exposure for NO(2) was associated with a 1.7% (95% confidence interval = 0.2%-3.3%) increase in fibrinogen for ozone; a 10.8% (2.2%-20.0%) increase in C-reactive protein for particle number; a 5.9% (3.6%-8.3%) increase in ICAM-1; and for PM(2.5), a 3.7% (1.7%-5.8%) increase in VCAM-1. The air pollution effect was stronger among subjects having higher Alu, lower LINE-1, tissue factor, or TLR-2 methylation status.
conclusionWe observed associations of traffic-related pollutants on fibrinogen, and both traffic and secondary particles on C-reactive protein, ICAM-1, and VCAM-1. There was effect modification by DNA methylation status, indicating that epigenetic states can convey susceptibility to air pollution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.