Trial reportThe American journal of clinical nutrition2012
Efficacy and safety of a short course of very-high-dose cholecalciferol in hemodialysis.
Trial report in The American journal of clinical nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00912782 (Impact of Vitamin D on Arteriovenous Fistulae Maturation Among ESRD Patients), which is not on this map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Vitamin D on Arteriovenous Fistulae Maturation Among ESRD Patients
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The effects of vitamin D on all-cause mortality in different diseases: an evidence-map and umbrella review of 116 randomized controlled trials.Frontiers in nutrition · 2023Pooled it
- The effects of vitamin D treatment on glycemic control, serum lipid profiles, and C-reactive protein in patients with chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials.International urology and nephrology · 2019Pooled it
- Pooled it
- Ergocalciferol Supplementation in Hemodialysis Patients With Vitamin D Deficiency: A Randomized Clinical Trial.Journal of the American Society of Nephrology : JASN · 2016Trial
- Long-term cholecalciferol administration in hemodialysis patients: a single-center randomized pilot study.Medical science monitor : international medical journal of experimental and clinical research · 2014Trial
- Trial
- Very high-dose cholecalciferol and arteriovenous fistula maturation in ESRD: a randomized, double-blind, placebo-controlled pilot study.The journal of vascular accessTrial
- Vitamin D and Vitamin D Analogues in Hemodialysis Patients: A Review of the Literature.International journal of molecular sciences · 2025Review
- Vitamin D: are all compounds equal?Clinical kidney journal · 2025Article
- Hemodialysis Patients May Benefit from Cholecalciferol Treatment Targeting High Level of 25(OH)D.Medicina (Kaunas, Lithuania) · 2024Observational
- The Efficacy and Safety of High-Dose Cholecalciferol Therapy in Hemodialysis Patients.Biomedicines · 2024Article
- The Association of Sleep Quality and Vitamin D Levels in Hemodialysis Patients.BioMed research international · 2021Article
- Cholecalciferol vs. Small Doses of Alfacalcidol vs. Placebo in Chronic Kidney Disease Patients on Hemodialysis: A Randomized Parallel Group Study.Frontiers in medicine · 2021Article
- Benefit-risk balance of native vitamin D supplementation in chronic hemodialysis: what can we learn from the major clinical trials and international guidelines?Renal failure · 2019Review
- Vitamin D prohormone in the treatment of secondary hyperparathyroidism in patients with chronic kidney disease.International journal of nephrology and renovascular disease · 2017Review
- Vitamin D in patients with chronic kidney disease: a position statement of the Working Group "Trace Elements and Mineral Metabolism" of the Italian Society of Nephrology.Journal of nephrology · 2016Review
- Efficiency of delivery observed treatment in hemodialysis patients: the example of the native vitamin D therapy.Journal of nephrology · 2016Observational
- Efficacy and safety of body weight-adapted oral cholecalciferol substitution in dialysis patients with vitamin D deficiency.BMC nephrology · 2015Article
- Effect of oral vitamin D analogs on mortality and cardiovascular outcomes among adults with chronic kidney disease: a meta-analysis.Clinical kidney journal · 2015Article
- Low Dietary Intake of Vitamin D and Vitamin D Deficiency in Hemodialysis Patients.Journal of nephrology & therapeutics · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundVitamin D deficiency is highly prevalent among hemodialysis patients, but little data exist in support of an optimal repletion regimen.
objectiveThe objective was to ascertain the efficacy of weekly very-high-dose cholecalciferol (vitamin D(3)) in correcting vitamin D insufficiency and deficiency in patients with stage 5D chronic kidney disease.
designWe conducted a prospective, double-blind, randomized controlled pilot study that compared placebo with very high doses of oral cholecalciferol for 3 wk (200,000 IU/wk) in hemodialysis patients. We examined the rate of correction of vitamin D insufficiency or deficiency and the effect of treatment on markers of mineral metabolism and routine laboratory variables.
resultsTwenty-seven subjects received placebo, and 25 received cholecalciferol. The majority (94%) of subjects had serum 25-hydroxyvitamin D [25(OH)D] concentrations <30 ng/mL. Study groups were similar with respect to baseline clinical characteristics, with the exception of hemoglobin concentrations, which were lower in the cholecalciferol-treated group (P < 0.04). At follow-up, 90.5% of subjects treated with cholecalciferol achieved serum 25(OH)D concentrations ≥30 ng/mL in contrast to 13.6% of the placebo group. There were no significant changes in serum calcium, phosphate, or intact parathyroid hormone during the study.
conclusionShort-term, high-dose oral cholecalciferol treatment of vitamin D deficiency in hemodialysis patients appears to be effective and with no evidence of toxic effects. This trial was registered at clinicaltrials.gov as NCT00912782.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.