Evidence map›Paper›PMID 22236914›Full record

ArticleThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease2012

Tuberculosis contact investigation in a high-burden setting: house or household?

S S Van Wyk, A M Mandalakas, D A Enarson, R P Gie, N Beyers, A C Hesseling

Abstract readComparative Study
In one paragraph

Article in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Source case identification in HIV-exposed infants and tuberculosis diagnosis in an isoniazid prevention study.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2016
    Trial
  4. Article
  5. Article
  6. Observational
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Consensus Statement on Research Definitions for Drug-Resistant Tuberculosis in Children.Journal of the Pediatric Infectious Diseases Society · 2013
    Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

S S Van WykDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa. susanvanwyk@sun.ac.za
A M Mandalakas
D A Enarson
R P Gie
N Beyers
A C Hesseling

Funding

Stellenbosch University Clinical Trial Unit, Cape Town, South AfricaUM1AI069521 · NIAID · STELLENBOSCH UNIVERSITY · PI Shaun Barnabas, Anneke Catharina Hesseling · 2012 to 2026
$21.5M
The Utility of Interferon-Gamma Release Assays in TB-HIV co-infected ChildrenR01AI076199 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI MANDALAKAS, ANNA M · 2007 to 2011
$2.7M
South Africa Tuberculosis AIDS Training (SATBAT)U2RTW007370 · FIC · WITS HEALTH CONSORTIUM (PTY), LTD · PI MARTINSON, NEIL A · 2007 to 2011
$1.9M
FIC NIH HHS U2R TW007370NIAID NIH HHS R01 AI076199NIAID NIH HHS UM1 AI069521PHS HHS 1U2RTW007370/3
6 · The paper itself

Abstract

settingA high tuberculosis (TB) burden setting, South Africa. Two frequently used definitions for 'household' are 1) 'all dwellings on the same plot of land that share the same residential address'; and 2) 'a group of persons who live together in the same dwelling unit and who have the same eating arrangements'.

objectiveTo characterise a household and the outcome of investigations in household child contacts using definition 1 compared to definition 2 during a TB contact investigation.

designAccess to a household (definition 1) was gained via an adult TB case. Children were assessed for TB infection and disease.

resultsHousehold enumeration indicated 25 members of three families living in a main house and a fourth family living in an adjacent structure. Three children were diagnosed with TB and two referred for isoniazid preventive therapy. Families living in the main house shared the main kitchen, while the yard house family used its own kitchen. This household would have been classified as two separate households if definition 2 had been used, and children with TB disease and infection would have been missed.

conclusionThe definition of household in TB contact investigation should provide a framework that is broad enough to capture the majority of children at risk.

Indexed as

Family CharacteristicsAdolescentAdultChildChild, PreschoolContact TracingFemaleHumansIncidenceRetrospective StudiesRisk AssessmentRisk FactorsSouth AfricaTuberculosisYoung Adult

Identifiers

PMID22236914
PMCPMC11969572

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.