ArticleJournal of natural products2012
Twilight zone sponges from Guam yield theonellin isocyanate and psammaplysins I and J.
Article in Journal of natural products, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Chemical Diversity and Biological Activities of Marine Sponges of the GenusMarine drugs · 2019Pooled it
- Marine Bromotyrosine Derivatives in Spotlight: Bringing Discoveries and Biological Significance.Marine drugs · 2024Review
- Naturally Occurring Organohalogen Compounds-A Comprehensive Review.Progress in the chemistry of organic natural products · 2023Review
- Total Synthesis of the Dihydrooxepine-Spiroisoxazoline Natural Product Psammaplysin A.Journal of the American Chemical Society · 2022Article
- Psammaplysins: Insights from Natural Sources, Structural Variations, and Pharmacological Properties.Marine drugs · 2022Review
- In Vitro Anticancer and Cancer-Preventive Activity of New Triterpene Glycosides from the Far Eastern StarfishMarine drugs · 2022Article
- Psammaceratin A: A Cytotoxic Psammaplysin Dimer Featuring an Unprecedented (2Z,3Z)-2,3-Bis(aminomethylene)succinamide Backbone from the Red Sea SpongeMarine drugs · 2021Article
- Cellular Signal Transductions and Their Inhibitors Derived from Deep-Sea Organisms.Marine drugs · 2021Review
- Discovery of Cymopolyphenols A-F From a Marine Mesophotic ZoneFrontiers in microbiology · 2021Article
- Synthesis and biological evaluation of fluoro-substituted spiro-isoxazolines as potential anti-viral and anti-cancer agents.RSC advances · 2020Article
- Cytotoxic Psammaplysin Analogues from the Verongid Red Sea SpongeBiomolecules · 2019Article
- The Oxepane Motif in Marine Drugs.Marine drugs · 2017Review
- Marine Isonitriles and Their Related Compounds.Marine drugs · 2016Review
- Article
- Syntheses and biological studies of marine terpenoids derived from inorganic cyanide.Natural product reports · 2015Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
From the organic extracts of two Guam sponges, Rhaphoxya sp. and Suberea sp., determined to have cytotoxic and chemopreventive activities, three new compounds, theonellin isocyanate (1) and psammaplysins I and J (5, 6), and six previously reported compounds (2-4, 7-9) were isolated and characterized spectroscopically ((1)H and (13)C NMR, MS, IR, UV, [α](D)). The two new metabolites (5 and 6) isolated from the Suberea sp. sponge are rare examples of compounds containing a bromotyramine moiety rather than the more usual dibromo analogue. For the compounds isolated from the Rhaphoxya sp., this is the first report of the known compounds 2-4 being found in a single sponge. For previously reported compounds 2-4 complete unambiguous (1)H and (13)C NMR data are provided.
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