ArticleApplied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme2012
Age-related changes in oxidative capacity differ between locomotory muscles and are associated with physical activity behavior.
Article in Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 3 of them syntheses that pooled it.
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Who cites it
56 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pooled it
- Pooled it
- Creatine supplementation and aging musculoskeletal health.Endocrine · 2014Pooled it
- Mechanisms underlying age-related changes in the human skeletal muscle bioenergetic system.European journal of applied physiology · 2026Article
- Neither intracellular oxygen availability nor mitochondrial coupling explain lower oxidative capacity in older human vastus lateralis muscle in vivo.The Journal of physiology · 2026Article
- Knee Health Is a Major Determinant of Mobility Across the Healthspan.Journal of functional morphology and kinesiology · 2025Review
- Mitochondrial diagnostics reveal diffuse impairments in skeletal muscle energetics in aging mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Developmental dynamics of mitochondrial fission and fusion proteins in functionally divergent skeletal muscles of goat.Physiological reports · 2024Article
- Near-infrared spectroscopy (NIRS)Frontiers in physiology · 2024Article
- Sarcopenic Obesity: Involvement of Oxidative Stress and Beneficial Role of Antioxidant Flavonoids.Antioxidants (Basel, Switzerland) · 2023Review
- Age-related changes in gait biomechanics and their impact on the metabolic cost of walking: Report from a National Institute on Aging workshop.Experimental gerontology · 2023Review
- Impact of aging on mitochondrial respiration in various organs.Physiological research · 2022Article
- Age-Related Changes in Skeletal Muscle Oxygen Utilization.Journal of functional morphology and kinesiology · 2022Review
- Differences in Physical Characteristics of the Lower Extremity and Running Biomechanics Between Different Age Groups.International journal of environmental research and public health · 2022Article
- Exercise intolerance and rapid skeletal muscle energetic decline in human age-associated frailty.JCI insight · 2020Article
- Article
- In vivo assessment of mitochondrial capacity using NIRS in locomotor muscles of young and elderly males with similar physical activity levels.GeroScience · 2020Article
- Bioenergetic basis for the increased fatigability with ageing.The Journal of physiology · 2019Article
- Review
- Moderate-to-Vigorous Physical Activity Is Associated With Higher Muscle Oxidative Capacity in Older Adults.Journal of the American Geriatrics Society · 2019Article
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4 authors.
Funding
Abstract
There is discrepancy in the literature regarding the degree to which old age affects muscle bioenergetics. These discrepancies are likely influenced by several factors, including variations in physical activity (PA) and differences in the muscle group investigated. To test the hypothesis that age may affect muscles differently, we quantified oxidative capacity of tibialis anterior (TA) and vastus lateralis (VL) muscles in healthy, relatively sedentary younger (8 YW, 8 YM; 21-35 years) and older (8 OW, 8 OM; 65-80 years) adults. To investigate the effect of physical activity on muscle oxidative capacity in older adults, we compared older sedentary women to older women with mild-to-moderate mobility impairment and lower physical activity (OIW, n = 7), and older sedentary men with older active male runners (OAM, n = 6). Oxidative capacity was measured in vivo as the rate constant, k(PCr), of postcontraction phosphocreatine recovery, obtained by (31)P magnetic resonance spectroscopy following maximal isometric contractions. While k(PCr) was higher in TA of older than activity-matched younger adults (28%; p = 0.03), older adults had lower k(PCr) in VL (23%; p = 0.04). In OIW compared with OW, k(PCr) was lower in VL (∼45%; p = 0.01), but not different in TA. In contrast, OAM had higher k(PCr) than OM (p = 0.03) in both TA (41%) and VL (54%). In older adults, moderate-to-vigorous PA was positively associated with k(PCr) in VL (r = 0.65, p < 0.001) and TA (r = 0.41, p = 0.03). Collectively, these results indicate that age-related changes in oxidative capacity vary markedly between locomotory muscles, and that altered PA behavior may play a role in these changes.
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