ArticleClinical and experimental immunology2012
Utility of peripheral blood B cell subsets analysis in common variable immunodeficiency.
Article in Clinical and experimental immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- B Cell Subsets in Colombian Adults with Predominantly Antibody Deficiencies, Bronchiectasis or Recurrent Pneumonia.Advances in respiratory medicine · 2022Article
- Lymphocyte Subgroups and KREC Numbers in Common Variable Immunodeficiency: A Single Center Study.Journal of clinical immunology · 2020Article
- Common Variable Immunodeficiency and Liver Involvement.Clinical reviews in allergy & immunology · 2018Review
- Lymphocyte Disturbances in Primary Antiphospholipid Syndrome and Application to Venous Thromboembolism Follow-Up.Clinical reviews in allergy & immunology · 2017Review
- The immunophenotypic fingerprint of patients with primary antibody deficiencies is partially present in their asymptomatic first-degree relatives.Haematologica · 2017Article
- The B-cell compartment in antibody-deficient infants and young children - developing common variable immunodeficiency or transient immune maturation?Italian journal of pediatrics · 2016Article
- Flow Cytometry, a Versatile Tool for Diagnosis and Monitoring of Primary Immunodeficiencies.Clinical and vaccine immunology : CVI · 2016Review
- Ill-defined germinal centers and severely reduced plasma cells are histological hallmarks of lymphadenopathy in patients with common variable immunodeficiency.Journal of clinical immunology · 2014Article
- Long-term follow-up on affinity maturation and memory B-cell generation in patients with common variable immunodeficiency.Journal of clinical immunology · 2013Article
- Outcomes of splenectomy in patients with common variable immunodeficiency (CVID): a survey of 45 patients.Clinical and experimental immunology · 2013Article
- Chipping away at a mountain: genomic studies in common variable immunodeficiency.Autoimmunity reviews · 2013Review
- Three different classifications, B lymphocyte subpopulations, TNFRSF13B (TACI), TNFRSF13C (BAFF-R), TNFSF13 (APRIL) gene mutations, CTLA-4 and ICOS gene polymorphisms in Turkish patients with common variable immunodeficiency.Journal of clinical immunology · 2012Article
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8 authors.
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Abstract
Abnormalities in peripheral blood B cell subsets have been identified in common variable immunodeficiency (CVID) patients and classification systems based upon their numbers have been proposed to predict the clinical features. We analysed B lymphocyte subsets by multi-colour flow cytometry (MFC) in a cohort of well-characterized CVID patients to look at their clinical relevance and validate the published association of different classification criteria (Freiburg, Paris and Euroclass) with clinical manifestations. CVID patients had a reduced proportion of total and switched memory B cells (MBC, swMBC) compared to normal controls (P < 0·0006). Patients classified in Freiburg Ia had a higher prevalence of granulomatous diseases (P = 0·0034). The previously published associations with autoimmune diseases could not be confirmed. The Euroclass classification was not predictive of clinical phenotypes. The absolute numbers of all B cell subsets were reduced in CVID patients compared to controls. There was a significant linear correlation between low absolute total B cells and MBC with granulomatous disease (P < 0·05) and a trend towards lower B cells in patients with autoimmune diseases (P = 0·07). Absolute number of different B cell subsets may be more meaningful than their relative percentages in assessing the risk of granulomatous diseases and possibly autoimmunity.
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