ArticleNeurogastroenterology and motility2012
Topographic and manometric characterization of the recto-anal inhibitory reflex.
Article in Neurogastroenterology and motility, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02782377 (Evaluation of the Rectal Reflex Using Anal Acoustic Reflectometry), which is not on this map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Rectal Reflex Using Anal Acoustic Reflectometry
Who cites it
25 citing papers in PubMed.
- The anorectal defaecation reflex: a prospective intervention study.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2022Trial
- Prolonged-Release Oxycodone/Naloxone Improves Anal Sphincter Relaxation Compared to Oxycodone Plus Macrogol 3350.Digestive diseases and sciences · 2017Trial
- Article
- Interrater reliability in pediatric high-resolution anorectal manometry recordings.Journal of pediatric gastroenterology and nutrition · 2026Article
- Diagnostic performance of three-dimensional high-resolution anorectal manometry in identifying descending perineal syndrome.Frontiers in medicine · 2026Article
- Multi-system benefits of non-invasive spinal cord stimulation following cervical spinal cord injury: a case study.Bioelectronic medicine · 2025Article
- High-resolution anorectal manometry for diagnosing obstructed defecation syndrome associated with moderate rectocele compared to healthy individuals.BMC gastroenterology · 2024Article
- Review of the indications, methods, and clinical utility of anorectal manometry and the rectal balloon expulsion test.Neurogastroenterology and motility · 2022Review
- Understanding the physiology of human defaecation and disorders of continence and evacuation.Nature reviews. Gastroenterology & hepatology · 2021Review
- Normal values for high-resolution anorectal manometry in healthy young adults: evidence from Vietnam.BMC gastroenterology · 2021Article
- Distal Colon Motor Coordination: The Role of the Coloanal Reflex and the Rectoanal Inhibitory Reflex in Sampling, Flatulence, and Defecation.Frontiers in medicine · 2021Article
- Changes in the parameters of the rectoanal inhibitory reflex in children with functional constipation and large rectum.Medicine and pharmacy reports · 2021Article
- Control of Motility in the Internal Anal Sphincter.Journal of neurogastroenterology and motility · 2019Article
- Three-dimensional high-resolution anorectal manometry in functional anorectal disorders: results from a large observational cohort study.International journal of colorectal disease · 2019Observational
- Comparison of inhibitory neuromuscular transmission in the Cynomolgus monkey IAS and rectum: special emphasis on differences in purinergic transmission.The Journal of physiology · 2018Article
- Anorectal Manometry in Defecatory Disorders: A Comparative Analysis of High-resolution Pressure Topography and Waveform Manometry.Journal of neurogastroenterology and motility · 2018Article
- Three-Dimensional Anorectal Manometry Enhances Diagnostic Gain by Detecting Sphincter Defects and Puborectalis Pressure.Digestive diseases and sciences · 2017Article
- How to Perform and Interpret a High-resolution Anorectal Manometry Test.Journal of neurogastroenterology and motility · 2016Article
- Role of Anorectal Manometry in Clinical Practice.Current treatment options in gastroenterology · 2015Article
- Accuracy and Reproducibility of High-definition Anorectal Manometry and Pressure Topography Analyses in Healthy Subjects.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundRecto-anal inhibitory reflex (RAIR) is an integral part of normal defecation. The physiologic characteristics of RAIR along anal length and anterior-posterior axis are unknown. The aim of this study was to perform topographic and vector-graphic evaluation of RAIR along anal canal using high definition manometry (HDM), and examine the role of various muscle components.
methodsAnorectal topography was assessed in 10 healthy volunteers using HDM probe with 256 sensors. Recto-anal inhibitory reflex data were analyzed every mm along the length of anal canal for topographic, baseline, residual, and plateau pressures during five mean volumes of balloon inflation (15 cc, 40 cc, 71 cc, 101 cc, 177 cc), and in 3D by dividing anal canal into 4 × 2.1 mm grids. KEY
resultsRelaxation pressure progressively increases along anal canal with increasing balloon volume up to 71 cc and thereafter plateaus. In 3D, RAIR is maximally seen at the middle and upper portions of anal canal (levels 1.2-3.2 cm) and posteriorly. Peak residual pressure was seen at proximal anal canal. CONCLUSIONS & INFERENCES: Recto-anal inhibitory reflex is characterized by differential anal relaxation along anterior-posterior axis, longitudinally along the length of anal canal, and it depends on the rectal distention volume. It is maximally seen at internal anal sphincter pressure zone. Multidimensional analyses indicate that external anal sphincter provides bulk of anal residual pressure. Our findings emphasize importance of sensor location and orientation; as anterior and more distal location may miss RAIR.
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