Evidence map›Paper›PMID 22235754›Full record

ArticleOrganic letters2012

Rapid access to conformational analogues of (+)-peloruside A.

Zhiming Zhao, Richard E Taylor

Abstract read
In one paragraph

Article in Organic letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Zhiming ZhaoDepartment of Chemistry and Biochemistry and the Mike and Josie Harper Cancer Research Institute, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, Indiana 46556-5670, USA.
Richard E Taylor

Funding

Conformation-Activity RelationshipsR01GM077683 · NIGMS · UNIVERSITY OF NOTRE DAME · PI TAYLOR, RICHARD E. · 2006 to 2009
$1.1M
NIGMS NIH HHS GM077683NIGMS NIH HHS R01 GM077683
6 · The paper itself

Abstract

An efficient synthetic strategy for rapid access to analogues of peloruside A has been demonstrated. The synthetic route was highlighted by a simple esterification-based fragment coupling and a late stage ring-closing metathesis reaction. This convergent route has provided access to rationally designed analogues inspired by the solution conformational preferences of peloruside A.

Indexed as

Bridged Bicyclo Compounds, HeterocyclicLactonesMacrolidesMolecular ConformationTime FactorsBridged Bicyclo Compounds, HeterocyclicLactonesMacrolidespeloruside Apeloruside B

Identifiers

PMID22235754
PMCPMC3272296

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.