ArticlePloS one2012
High phosphorus diet-induced changes in NaPi-IIb phosphate transporter expression in the rat kidney: DNA microarray analysis.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Downregulation of the kidney glucagon receptor, essential for renal function and systemic homeostasis, contributes to chronic kidney disease.Cell metabolism · 2024Article
- Modulating phosphate consumption, a novel therapeutic approach for the control of cancer cell proliferation and tumorigenesis.Biochemical pharmacology · 2021Review
- Reduced phosphorus intake throughout gestation and lactation of sows is mitigated by transcriptional adaptations in kidney and intestine.BMC genomics · 2020Article
- Expression of NaPi-IIb in rodent and human kidney and upregulation in a model of chronic kidney disease.Pflugers Archiv : European journal of physiology · 2020Article
- Dietary Lead and Phosphate Interactions Affect Oral Bioavailability of Soil Lead in the Mouse.Environmental science & technology · 2019Article
- Renal ischemia-reperfusion injury impairs renal calcium, magnesium, and phosphate handling in mice.Pflugers Archiv : European journal of physiology · 2019Article
- Physiological regulation of phosphate by vitamin D, parathyroid hormone (PTH) and phosphate (Pi).Pflugers Archiv : European journal of physiology · 2019Review
- The role of SLC34A2 in intestinal phosphate absorption and phosphate homeostasis.Pflugers Archiv : European journal of physiology · 2019Review
- The Gα12/13-coupled receptor LPA4 limits proper adipose tissue expansion and remodeling in diet-induced obesity.JCI insight · 2018Article
- The Body-wide Transcriptome Landscape of Disease Models.iScience · 2018Article
- Lowered dietary phosphorus affects intestinal and renal gene expression to maintain mineral homeostasis with immunomodulatory implications in weaned piglets.BMC genomics · 2018Article
- Identification of a mammalian silicon transporter.American journal of physiology. Cell physiology · 2017Article
- Identification of BCL11B as a regulator of adipogenesis.Scientific reports · 2016Article
- The Brewed Rice Vinegar Kurozu Increases HSPA1A Expression and Ameliorates Cognitive Dysfunction in Aged P8 Mice.PloS one · 2016Article
- A High Phosphorus Diet Affects Lipid Metabolism in Rat Liver: A DNA Microarray Analysis.PloS one · 2016Article
- Deregulated Renal Calcium and Phosphate Transport during Experimental Kidney Failure.PloS one · 2015Article
- The phosphate transporter NaPi-IIa determines the rapid renal adaptation to dietary phosphate intake in mouse irrespective of persistently high FGF23 levels.Pflugers Archiv : European journal of physiology · 2013Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanism by which phosphorus levels are maintained in the body was investigated by analyzing changes in gene expression in the rat kidney following administration of a high phosphorus (HP) diet. Male Wistar rats were divided into two groups and fed a diet containing 0.3% (control) or 1.2% (HP) phosphorous for 24 days. Phosphorous retention was not significantly increased in HP rats, but fractional excretion of phosphorus was significantly increased in the HP group compared to controls, with an excessive amount of the ingested phosphorus being passed through the body. DNA microarray analysis of kidney tissue from both groups revealed changes in gene expression profile induced by a HP diet. Among the genes that were upregulated, Gene Ontology (GO) terms related to ossification, collagen fibril organization, and inflammation and immune response were significantly enriched. In particular, there was significant upregulation of type IIb sodium-dependent phosphate transporter (NaPi-IIb) in the HP rat kidney compared to control rats. This upregulation was confirmed by in situ hybridization. Distinct signals for NaPi-IIb in both the cortex and medulla of the kidney were apparent in the HP group, while the corresponding signals were much weaker in the control group. Immunohistochemical analysis showed that NaPi-IIb localized to the basolateral side of kidney epithelial cells surrounding the urinary duct in HP rats but not in control animals. These data suggest that NaPi-IIb is upregulated in the kidney in response to the active excretion of phosphate in HP diet-fed rats.
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