Trial reportPloS one2012
Clinical subtypes of depression are associated with specific metabolic parameters and circadian endocrine profiles in women: the power study.
Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00006180 (The P.O.W.E.R. STUDY), which is not on this map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The P.O.W.E.R. STUDY (Premenopause, Osteopenia/Osteoporosis, Women, Alendronate, Depression)
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Insulin resistance in depression: A large meta-analysis of metabolic parameters and variation.Neuroscience and biobehavioral reviews · 2022Pooled it
- Acute ketamine administration corrects abnormal inflammatory bone markers in major depressive disorder.Molecular psychiatry · 2018Trial
- Do premenopausal women with major depression have low bone mineral density? A 36-month prospective study.PloS one · 2012Trial
- Monocyte epigenetic age acceleration is linked to non-somatic depressive symptoms in women with and without HIV.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Familial and genetic relationships of major depressive disorders and adiposity markers in the community.Translational psychiatry · 2025Article
- Differences in the 24-h autonomic nervous activity of outpatients with major depressive disorder with or without hypersomnia: An exploratory observational study.BioPsychoSocial medicine · 2025Article
- Association Between Depression Severity and Ovarian Cancer Among American Women: A Cross-Sectional Study.International journal of women's health · 2025Article
- Leptin and leptin receptor gene polymorphisms and depression treatment response.Acta neuropsychiatrica · 2024Article
- Associations of somatic depressive symptoms with body mass index, systemic inflammation, and insulin resistance in primary care patients with depression.Journal of behavioral medicine · 2022Article
- Dietary Patterns are Differentially Associated with Atypical and Melancholic Subtypes of Depression.Nutrients · 2021Article
- Obesity and atypical depression symptoms: findings from Mendelian randomization in two European cohorts.Translational psychiatry · 2021Article
- Peripheral Markers of Depression.Journal of clinical medicine · 2020Review
- Depression and Obesity: Analysis of Common Biomarkers.Diseases (Basel, Switzerland) · 2020Review
- Effects of Neurological Disorders on Bone Health.Frontiers in psychology · 2020Review
- Hormonal Function Responses to Moderate Aerobic Exercise in Older Adults with Depression.Clinical interventions in aging · 2020Article
- Toward a New Model of Understanding, Preventing, and Treating Adolescent Depression Focusing on Exhaustion and Stress.Frontiers in psychiatry · 2020Article
- 12-year changes in cardiovascular risk factors in people with major depressive or bipolar disorder: a prospective cohort analysis in Germany.European archives of psychiatry and clinical neuroscience · 2019Article
- Biomarker-based subtyping of depression and anxiety disorders using Latent Class Analysis. A NESDA study.Psychological medicine · 2019Article
- Depression and obesity: evidence of shared biological mechanisms.Molecular psychiatry · 2019Review
- Leptin in depression: a potential therapeutic target.Cell death & disease · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
backgroundMajor depressive disorder (MDD) has been associated with adverse medical consequences, including cardiovascular disease and osteoporosis. Patients with MDD may be classified as having melancholic, atypical, or undifferentiated features. The goal of the present study was to assess whether these clinical subtypes of depression have different endocrine and metabolic features and consequently, varying medical outcomes.
methodsPremenopausal women, ages 21 to 45 years, with MDD (N = 89) and healthy controls (N = 44) were recruited for a prospective study of bone turnover. Women with MDD were classified as having melancholic (N = 51), atypical (N = 16), or undifferentiated (N = 22) features. Outcome measures included: metabolic parameters, body composition, bone mineral density (BMD), and 24 hourly sampling of plasma adrenocorticotropin (ACTH), cortisol, and leptin.
resultsCompared with control subjects, women with undifferentiated and atypical features of MDD exhibited greater BMI, waist/hip ratio, and whole body and abdominal fat mass. Women with undifferentiated MDD characteristics also had higher lipid and fasting glucose levels in addition to a greater prevalence of low BMD at the femoral neck compared to controls. Elevated ACTH levels were demonstrated in women with atypical features of depression, whereas higher mean 24-hour leptin levels were observed in the melancholic subgroup.
conclusionsPre-menopausal women with various features of MDD exhibit metabolic, endocrine, and BMD features that may be associated with different health consequences.
trial registrationClinicalTrials.gov NCT00006180.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.