ArticlePloS one2012
African ancestry is associated with asthma risk in African Americans.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Temporal trends and racial/ethnic disparity in self-reported pediatric food allergy in the United States.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2014Pooled it
- Exacerbation-prone asthma in the context of race and ancestry in Asthma Clinical Research Network trials.The Journal of allergy and clinical immunology · 2019Trial
- Shared Genetic Susceptibility Between Asthma and Immune-Mediated Inflammatory Diseases.Canadian respiratory journal · 2026Article
- Uterine leiomyomata and keloids fibrosis origins: a mini-review of fibroproliferative diseases.American journal of physiology. Cell physiology · 2023Review
- Asthma Exacerbations: The Genes Behind the Scenes.Journal of investigational allergology & clinical immunology · 2023Review
- Environmental justice and allergic disease: A Work Group Report of the AAAAI Environmental Exposure and Respiratory Health Committee and the Diversity, Equity and Inclusion Committee.The Journal of allergy and clinical immunology · 2023Article
- Multiancestral polygenic risk score for pediatric asthma.The Journal of allergy and clinical immunology · 2022Article
- Developing CIRdb as a catalog of natural genetic variation in the Canary Islanders.Scientific reports · 2022Article
- The association between Herpes simplex virus type 2 and asthma: A cross-sectional study from National Health and Nutrition Examination Survey 1999-2016.Frontiers in medicine · 2022Article
- Role of Sex on the Genetic Susceptibility to Childhood Asthma in Latinos and African Americans.Journal of personalized medicine · 2021Article
- The Role of Genetic Ancestry as a Risk Factor for Primary Open-angle Glaucoma in African Americans.Investigative ophthalmology & visual science · 2021Article
- Genome-wide association study reveals a novel locus for asthma with severe exacerbations in diverse populations.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2021Article
- Potentially avoidable hospitalization for asthma in children and adolescents by migrant status: results from the Italian Network for Longitudinal Metropolitan Studies.BMC public health · 2020Article
- Review
- Comparison of severity of asthma hospitalization between African American and Hispanic children in the Bronx.The Journal of asthma : official journal of the Association for the Care of Asthma · 2020Article
- A Pediatric Asthma Risk Score to better predict asthma development in young children.The Journal of allergy and clinical immunology · 2019Article
- GlobAl Distribution of GEnetic Traits (GADGET) web server: polygenic trait scores worldwide.Nucleic acids research · 2018Article
- Established and Emerging Environmental Contributors to Disparities in Asthma and Chronic Obstructive Pulmonary Disease.Current epidemiology reports · 2018Article
- Caring for Young Children with Asthma: Perspectives from Urban Community Health Centers.Journal of urban health : bulletin of the New York Academy of Medicine · 2017Article
- Health Disparities in Patients with Pulmonary Arterial Hypertension: A Blueprint for Action. An Official American Thoracic Society Statement.American journal of respiratory and critical care medicine · 2017Review
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundAsthma is a common complex condition with clear racial and ethnic differences in both prevalence and severity. Asthma consultation rates, mortality, and severe symptoms are greatly increased in African descent populations of developed countries. African ancestry has been associated with asthma, total serum IgE and lower pulmonary function in African-admixed populations. To replicate previous findings, here we aimed to examine whether African ancestry was associated with asthma susceptibility in African Americans. In addition, we examined for the first time whether African ancestry was associated with asthma exacerbations. METHODOLOGY/PRINCIPAL
findingsAfter filtering for self-reported ancestry and genotype data quality, samples from 1,117 self-reported African-American individuals from New York and Baltimore (394 cases, 481 controls), and Chicago (321 cases followed for asthma exacerbations) were analyzed. Genetic ancestry was estimated based on ancestry informative markers (AIMs) selected for being highly divergent among European and West African populations (95 AIMs for New York and Baltimore, and 66 independent AIMs for Chicago). Among case-control samples, the mean African ancestry was significantly higher in asthmatics than in non-asthmatics (82.0±14.0% vs. 77.8±18.1%, mean difference 4.2% [95% confidence interval (CI):2.0-6.4], p<0.0001). This association remained significant after adjusting for potential confounders (odds ratio: 4.55, 95% CI: 1.69-12.29, p = 0.003). African ancestry failed to show an association with asthma exacerbations (p = 0.965) using a model based on longitudinal data of the number of exacerbations followed over 1.5 years. CONCLUSIONS/SIGNIFICANCE: These data replicate previous findings indicating that African ancestry constitutes a risk factor for asthma and suggest that elevated asthma rates in African Americans can be partially attributed to African genetic ancestry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.