ArticleEvidence-based complementary and alternative medicine : eCAM2012
Comprehensive evidence-based assessment and prioritization of potential antidiabetic medicinal plants: a case study from canadian eastern james bay cree traditional medicine.
Article in Evidence-based complementary and alternative medicine : eCAM, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- From Plant Chemistry to Reproducible Antidiabetic Products: A Critical Review of Molecular Targets, Clinical Evidence, and Translational Gaps.Molecules (Basel, Switzerland) · 2026Review
- Comparative Evaluation of the Antidiabetic, Hypolipidemic and Antioxidant Effects ofMolecules (Basel, Switzerland) · 2026Article
- A Multivariate Approach to Ethnopharmacology: Antidiabetic Plants of Eeyou Istchee.Frontiers in pharmacology · 2021Review
- Barriers and Mitigating Strategies to Healthcare Access in Indigenous Communities of Canada: A Narrative Review.Healthcare (Basel, Switzerland) · 2020Review
- Understanding glycaemic control and current approaches for screening antidiabetic natural products from evidence-based medicinal plants.Plant methods · 2019Review
- Anti-apoptotic potential of several antidiabetic medicinal plants of the eastern James Bay Cree pharmacopeia in cultured kidney cells.BMC complementary and alternative medicine · 2018Article
- Phytogeographic and genetic variation inPeerJ · 2016Article
- Article
- Anti-hyperglycemic effect of bilberry, blackberry and mulberry ultrasonic extracts on diabetic rats.Plant foods for human nutrition (Dordrecht, Netherlands) · 2013Article
- The action of antidiabetic plants of the canadian james bay cree traditional pharmacopeia on key enzymes of hepatic glucose homeostasis.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Characterizing the cytoprotective activity of Sarracenia purpurea L., a medicinal plant that inhibits glucotoxicity in PC12 cells.BMC complementary and alternative medicine · 2012Article
- Diabetes mellitus and the Aboriginal diabetic initiative in Canada: An update review.Journal of family medicine and primary careReview
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Authors and funding
26 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Canadian Aboriginals, like others globally, suffer from disproportionately high rates of diabetes. A comprehensive evidence-based approach was therefore developed to study potential antidiabetic medicinal plants stemming from Canadian Aboriginal Traditional Medicine to provide culturally adapted complementary and alternative treatment options. Key elements of pathophysiology of diabetes and of related contemporary drug therapy are presented to highlight relevant cellular and molecular targets for medicinal plants. Potential antidiabetic plants were identified using a novel ethnobotanical method based on a set of diabetes symptoms. The most promising species were screened for primary (glucose-lowering) and secondary (toxicity, drug interactions, complications) antidiabetic activity by using a comprehensive platform of in vitro cell-based and cell-free bioassays. The most active species were studied further for their mechanism of action and their active principles identified though bioassay-guided fractionation. Biological activity of key species was confirmed in animal models of diabetes. These in vitro and in vivo findings are the basis for evidence-based prioritization of antidiabetic plants. In parallel, plants were also prioritized by Cree Elders and healers according to their Traditional Medicine paradigm. This case study highlights the convergence of modern science and Traditional Medicine while providing a model that can be adapted to other Aboriginal realities worldwide.
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Registered trials
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