Trial reportBMJ (Clinical research ed.)2012
Vitamin A supplementation in preschool children and risk of hearing loss as adolescents and young adults in rural Nepal: randomised trial cohort follow-up study.
Trial report in BMJ (Clinical research ed.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 5 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Transformative applications of oculomics-based AI approaches in the management of systemic diseases: A systematic review.Journal of advanced research · 2025Pooled it
- Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age.The Cochrane database of systematic reviews · 2022Pooled it
- Assessment of the Clinical Benefit of Imaging in Children With Unilateral Sensorineural Hearing Loss: A Systematic Review and Meta-analysis.JAMA otolaryngology-- head & neck surgery · 2019Pooled it
- Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age.The Cochrane database of systematic reviews · 2017Pooled it
- Effect of antioxidant supplementation on the auditory threshold in sensorineural hearing loss: a meta-analysis.Brazilian journal of otorhinolaryngologyPooled it
- Effect of a participatory intervention in women's self-help groups for the prevention of chronic suppurative otitis media in their children in Jumla Nepal: a cluster-randomised trial.BMC pediatrics · 2019Trial
- Hearing loss is associated with decreased nonverbal intelligence in rural Nepal.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2015Trial
- Prevalence and risk factors of elevated blood pressure, overweight, and dyslipidemia in adolescent and young adults in rural Nepal.Metabolic syndrome and related disorders · 2013Trial
- Early childhood height is a determinant of young adult stature in rural Nepal.BMC public health · 2024Article
- A Case Report of Malignant Cerebellopontine Angle Lesion Highlighting the Interdisciplinary Diagnostic Challenge in the Case of Unilateral Progressive Hearing Loss.Journal of clinical medicine · 2024Article
- Diabetes mellitus and hearing loss.Molecular medicine (Cambridge, Mass.) · 2023Review
- Retinol and Pro-Vitamin A Carotenoid Nutritional Status during Pregnancy Is Associated with Newborn Hearing Screen Results.Nutrients · 2023Article
- The Role of Vitamins A and E Level in Chronic Suppurative Otitis Media with and without Cholesteatoma.Journal of multidisciplinary healthcare · 2023Article
- A Review of Vitamin A Supplementation in South Sudan: Successes, Challenges, and Opportunities for the Way Forward.Global health, science and practice · 2022Review
- To see, hear, and live: 25 years of the vitamin A programme in Nepal.Maternal & child nutrition · 2022Article
- Opinion: Allow Golden Rice to save lives.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Assessment of auditory function and lipid levels in patients receiving oral isotretinoin (13-Postepy dermatologii i alergologii · 2020Article
- Vitamin A and Pregnancy: A Narrative Review.Nutrients · 2019Review
- Interplay between Nutrition and Hearing Loss: State of Art.Nutrients · 2018Review
- Progressive hearing loss in vitamin A-deficient mice which may be protected by the activation of cochlear melanocyte.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine whether vitamin A supplementation administered in the preschool years can lower the risk of hearing loss in adolescence and adulthood.
designFollow-up study of adolescents and young adults who, as preschool aged children in 1989, were enrolled into a cluster randomised, double blinded, placebo controlled trial of vitamin A supplementation.
settingSouth central, rural Nepal.
participants2378 adolescents and young adults aged 14 to 23, representing 51% of those who finished the original trial and 71% of those living in the study area in 2006.
interventionsEvery four months for 16 months preschool children were visited at home, given an oral 200,000 IU dose of vitamin A (half dose at age 1-11 months, quarter dose at <1 month) or placebo and the parents were queried about any childhood illnesses in the previous week, including purulent discharge from the ears.
main outcome measuresPrevalence of mild or worse hearing loss (≥ 30 dB) in the most affected ear and tympanometric measures of middle ear function (peak height, ear canal volume, and gradient).
resultsDuring the original trial, the prevalence of middle ear infection during the preschool years did not differ between the supplement groups. By adolescence and early adulthood, a non-significant 17% reduction in hearing loss occurred among those who had periodically received vitamin A compared with placebo as preschool aged children (odds ratio 0.83, 95% confidence interval 0.62 to 1.12). Among participants with any ear discharge in early childhood, vitamin A supplementation was associated with a reduced risk of hearing loss, by 42% (0.58, 0.37 to 0.92) compared with controls, after adjusting the confidence interval for the design effect of the original trial. Abnormal tympanometric peak height of the middle ear system was less likely among participants supplemented with vitamin A in childhood.
conclusionIn undernourished settings, periodic, high dose vitamin A supplementation may reduce the risk of hearing loss associated with purulent ear infections in early childhood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.