ArticleNucleic acids research2012
The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Cellular Senescence Triggered by Food and Environmental Genotoxins.International journal of molecular sciences · 2026Review
- Article
- In silico study reveals unconventional interactions between MDC1 of DDR and Beclin-1 of autophagy.Molecular diversity · 2023Article
- DNA damage response revisited: the p53 family and its regulators provide endless cancer therapy opportunities.Experimental & molecular medicine · 2022Review
- Immediate-Early, Early, and Late Responses to DNA Double Stranded Breaks.Frontiers in genetics · 2022Review
- Dynamic recruitment of UFM1-specific peptidase 2 to the DNA double-strand breaks regulated by WIP1.Genome instability & disease · 2022Article
- Article
- Article
- Ubiquitin and ubiquitin-like molecules in DNA double strand break repair.Cell & bioscience · 2020Review
- MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance.Nature communications · 2019Article
- UFL1 promotes histone H4 ufmylation and ATM activation.Nature communications · 2019Article
- Article
- Ring finger protein 126 (RNF126) suppresses ionizing radiation-induced p53-binding protein 1 (53BP1) focus formation.The Journal of biological chemistry · 2018Article
- DNA Damage Response-Independent Role for MDC1 in Maintaining Genomic Stability.Molecular and cellular biology · 2017Article
- The multifaceted influence of histone deacetylases on DNA damage signalling and DNA repair.Nucleic acids research · 2016Review
- DICER, DROSHA and DNA damage response RNAs are necessary for the secondary recruitment of DNA damage response factors.Journal of cell science · 2016Article
- Versatility in phospho-dependent molecular recognition of the XRCC1 and XRCC4 DNA-damage scaffolds by aprataxin-family FHA domains.DNA repair · 2015Article
- Dimerization Mediated by a Divergent Forkhead-associated Domain Is Essential for the DNA Damage and Spindle Functions of Fission Yeast Mdb1.The Journal of biological chemistry · 2015Article
- BCL10 regulates RNF8/RNF168-mediated ubiquitination in the DNA damage response.Cell cycle (Georgetown, Tex.) · 2014Article
- Double strand break repair functions of histone H2AX.Mutation research · 2013Review
Corrections and comments
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Authors and funding
16 authors at 1 institution in 3 countries.
Funding
Abstract
Mdc1 is a large modular phosphoprotein scaffold that maintains signaling and repair complexes at double-stranded DNA break sites. Mdc1 is anchored to damaged chromatin through interaction of its C-terminal BRCT-repeat domain with the tail of γH2AX following DNA damage, but the role of the N-terminal forkhead-associated (FHA) domain remains unclear. We show that a major binding target of the Mdc1 FHA domain is a previously unidentified DNA damage and ATM-dependent phosphorylation site near the N-terminus of Mdc1 itself. Binding to this motif stabilizes a weak self-association of the FHA domain to form a tight dimer. X-ray structures of free and complexed Mdc1 FHA domain reveal a 'head-to-tail' dimerization mechanism that is closely related to that seen in pre-activated forms of the Chk2 DNA damage kinase, and which both positively and negatively influences Mdc1 FHA domain-mediated interactions in human cells prior to and following DNA damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.