ArticleGenetics2012
Gene genealogies within a fixed pedigree, and the robustness of Kingman's coalescent.
Article in Genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- From Nuisance to Signal: Leveraging Close Relatives in Biobank-Scale Demographic Inference.bioRxiv : the preprint server for biology · 2026Article
- Recent Statistical Innovations in Human Genetics.Annals of human genetics · 2025Review
- Effects of Social Structure on Effective Population Size Change Estimates.Evolutionary applications · 2025Article
- Article
- On the number of genealogical ancestors tracing to the source groups of an admixed population.Genetics · 2023Article
- Genome Evolution and the Future of Phylogenomics of Non-Avian Reptiles.Animals : an open access journal from MDPI · 2023Review
- Pedigree in the biparental Moran model.Journal of mathematical biology · 2022Article
- Efficient ancestry and mutation simulation with msprime 1.0.Genetics · 2022Article
- Pseudoreplication in genomic-scale data sets.Molecular ecology resources · 2022Article
- Variance and limiting distribution of coalescence times in a diploid model of a consanguineous population.Theoretical population biology · 2021Article
- Complex genetic admixture histories reconstructed with Approximate Bayesian Computation.Molecular ecology resources · 2021Article
- Distinguishing pedigree relationships via multi-way identity by descent sharing and sex-specific genetic maps.American journal of human genetics · 2021Article
- Accounting for long-range correlations in genome-wide simulations of large cohorts.PLoS genetics · 2020Article
- Joint Estimation of Pedigrees and Effective Population Size Using Markov Chain Monte Carlo.Genetics · 2019Article
- Article
- Tree-sequence recording in SLiM opens new horizons for forward-time simulation of whole genomes.Molecular ecology resources · 2019Article
- Efficient pedigree recording for fast population genetics simulation.PLoS computational biology · 2018Article
- On the number of siblings and p-th cousins in a large population sample.Journal of mathematical biology · 2018Article
- Inferring Identical-by-Descent Sharing of Sample Ancestors Promotes High-Resolution Relative Detection.American journal of human genetics · 2018Article
- Composite likelihood method for inferring local pedigrees.PLoS genetics · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We address a conceptual flaw in the backward-time approach to population genetics called coalescent theory as it is applied to diploid biparental organisms. Specifically, the way random models of reproduction are used in coalescent theory is not justified. Instead, the population pedigree for diploid organisms--that is, the set of all family relationships among members of the population--although unknown, should be treated as a fixed parameter, not as a random quantity. Gene genealogical models should describe the outcome of the percolation of genetic lineages through the population pedigree according to Mendelian inheritance. Using simulated pedigrees, some of which are based on family data from 19th century Sweden, we show that in many cases the (conceptually wrong) standard coalescent model is difficult to reject statistically and in this sense may provide a surprisingly accurate description of gene genealogies on a fixed pedigree. We study the differences between the fixed-pedigree coalescent and the standard coalescent by analysis and simulations. Differences are apparent in recent past, within ≈ <log(2)(N) generations, but then disappear as genetic lineages are traced into the more distant past.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.