ArticleThe EMBO journal2012
RP58 controls neuron and astrocyte differentiation by downregulating the expression of Id1-4 genes in the developing cortex.
Article in The EMBO journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- p21/Zbtb18 repress the expression of cKit to regulate the self-renewal of hematopoietic stem cells.Protein & cell · 2024Article
- Minocycline prevents early age-related cognitive decline in a mouse model of intellectual disability caused by ZBTB18/RP58 haploinsufficiency.Journal of neuroinflammation · 2024Article
- The murine metastatic microenvironment of experimental brain metastases of breast cancer differs by host age in vivo: a proteomic study.Clinical & experimental metastasis · 2024Article
- Deubiquitinase Mysm1 regulates neural stem cell proliferation and differentiation by controlling Id4 expression.Cell death & disease · 2024Article
- A novel heterozygous ZBTB18 missense mutation in a family with non-syndromic intellectual disability.Neurogenetics · 2023Article
- Chicken pituitary transcriptomic responses to acute heat stress.Molecular biology reports · 2023Article
- The mouse model of intellectual disability by ZBTB18/RP58 haploinsufficiency shows cognitive dysfunction with synaptic impairment.Molecular psychiatry · 2023Article
- Understanding the impact of ZBTB18 missense variation on transcription factor function in neurodevelopment and disease.Journal of neurochemistry · 2022Review
- RP58 Represses Transcriptional Programs Linked to Nonneuronal Cell Identity and Glioblastoma Subtypes in Developing Neurons.Molecular and cellular biology · 2021Article
- Article
- Rp58 and p27Neural development · 2017Article
- Pharmacogenomic identification of small molecules for lineage specific manipulation of subventricular zone germinal activity.PLoS biology · 2017Article
- Insights into the Biology and Therapeutic Applications of Neural Stem Cells.Stem cells international · 2016Review
- Huntington's disease biomarker progression profile identified by transcriptome sequencing in peripheral blood.European journal of human genetics : EJHG · 2015Article
- Global transcriptome profiling of genes that are differentially regulated during differentiation of mouse embryonic neural stem cells into astrocytes.Journal of molecular neuroscience : MN · 2015Article
- Molecular Pathways Underlying Projection Neuron Production and Migration during Cerebral Cortical Development.Frontiers in neuroscience · 2015Review
- A de novo non-sense mutation in ZBTB18 in a patient with features of the 1q43q44 microdeletion syndrome.European journal of human genetics : EJHG · 2014Article
- The ID proteins: master regulators of cancer stem cells and tumour aggressiveness.Nature reviews. Cancer · 2014Review
- Article
- Id-1 plays a key role in cell adhesion in neural stem cells through the preservation of RAP1 signaling.Cell adhesion & migrationArticle
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Appropriate number of neurons and glial cells is generated from neural stem cells (NSCs) by the regulation of cell cycle exit and subsequent differentiation. Although the regulatory mechanism remains obscure, Id (inhibitor of differentiation) proteins are known to contribute critically to NSC proliferation by controlling cell cycle. Here, we report that a transcriptional factor, RP58, negatively regulates all four Id genes (Id1-Id4) in developing cerebral cortex. Consistently, Rp58 knockout (KO) mice demonstrated enhanced astrogenesis accompanied with an excess of NSCs. These phenotypes were mimicked by the overexpression of all Id genes in wild-type cortical progenitors. Furthermore, Rp58 KO phenotypes were rescued by the knockdown of all Id genes in mutant cortical progenitors but not by the knockdown of each single Id gene. Finally, we determined p57 as an effector gene of RP58-Id-mediated cell fate control. These findings establish RP58 as a novel key regulator that controls the self-renewal and differentiation of NSCs and restriction of astrogenesis by repressing all Id genes during corticogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.