ArticleEuropean journal of human genetics : EJHG2012
Low prevalence of lactase persistence in Neolithic South-West Europe.
Article in European journal of human genetics : EJHG, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 77 citations in OpenAlex.
- Revealing Joseon period People's single nucleotide polymorphism associated with lactase gene by ancient DNA analysis of human remains from archaeological sites in Korea.Anatomy & cell biology · 2023Article
- Estimating prevalence of human traits among populations from polygenic risk scores.Human genomics · 2021Article
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- Integrating Family-Based and Mendelian Randomization Designs.Cold Spring Harbor perspectives in medicine · 2021Review
- Ancient proteins provide evidence of dairy consumption in eastern Africa.Nature communications · 2021Article
- Genetics of Lactose Intolerance: An Updated Review and Online Interactive World Maps of Phenotype and Genotype Frequencies.Nutrients · 2020Review
- Latitudinal gradient in dairy production with the introduction of farming in Atlantic Europe.Nature communications · 2020Article
- The Pastoral Origin of Semiotically Functional Tonal Organization of Music.Frontiers in psychology · 2020Article
- Article
- Ancient proteins from ceramic vessels at Çatalhöyük West reveal the hidden cuisine of early farmers.Nature communications · 2018Article
- World-wide distributions of lactase persistence alleles and the complex effects of recombination and selection.Human genetics · 2017Article
- Evolutionary Patterns and Processes: Lessons from Ancient DNA.Systematic biology · 2017Review
- Regional asynchronicity in dairy production and processing in early farming communities of the northern Mediterranean.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Going global by adapting local: A review of recent human adaptation.Science (New York, N.Y.) · 2016Review
- Methods and models for unravelling human evolutionary history.Nature reviews. Genetics · 2015Review
- The utility of ancient human DNA for improving allele age estimates, with implications for demographic models and tests of natural selection.Journal of human evolution · 2015Article
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- Toward a new history and geography of human genes informed by ancient DNA.Trends in genetics : TIG · 2014Review
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability of humans to digest the milk component lactose after weaning requires persistent production of the lactose-converting enzyme lactase. Genetic variation in the promoter of the lactase gene (LCT) is known to be associated with lactase production and is therefore a genetic determinant for either lactase deficiency or lactase persistence during adulthood. Large differences in this genetic trait exist between populations in Africa and the Middle-East on the one hand, and European populations on the other; this is thought to be due to evolutionary pressures exerted by consumption of dairy products in Neolithic populations in Europe. In this study, we have investigated lactase persistence of 26 out of 46 individuals from Late Neolithic through analysis of ancient South-West European DNA samples, obtained from two burials in the Basque Country originating from 5000 to 4500 YBP. This investigation revealed that these populations had an average frequency of lactase persistence of 27%, much lower than in the modern Basque population, which is compatible with the concept that Neolithic and post-Neolithic evolutionary pressures by cattle domestication and consumption of dairy products led to high lactase persistence in Southern European populations. Given the heterogeneity in the frequency of the lactase persistence allele in ancient Europe, we suggest that in Southern Europe the selective advantage of lactose assimilation in adulthood most likely took place from standing population variation, after cattle domestication, at a post-Neolithic time when fresh milk consumption was already fully adopted as a consequence of a cultural influence.
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