Evidence map›Paper›PMID 22233972›Full record

ArticleMathematical biosciences2012

A low dimensional dynamical model of the initial pulmonary innate response to infection.

Todd R Young, Richard Buckalew, Addison K May, Erik M Boczko

Abstract readComparative Study
In one paragraph

Article in Mathematical biosciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Early treatment gains for antibiotic administration and within human host time series data.Mathematical medicine and biology : a journal of the IMA · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Todd R YoungMathematics, Ohio University, Athens, OH 45701, USA. toddryoung@gmail.com
Richard Buckalew
Addison K May
Erik M Boczko

Funding

Dynamics and Bifurcations of Population Structures Induced by Cell Cycle FeedbackR01GM090207 · NIGMS · VANDERBILT UNIVERSITY · PI BOCZKO, ERIK MIKLOS · 2009 to 2012
$1.2M
NIGMS NIH HHS R01 GM090207
6 · The paper itself

Abstract

In order to gain a deeper understanding of the onset and progression of pulmonary infections we present and analyze a low dimensional, phenomenological model of infection and the innate immune response in the lungs. Because pulmonary innate immunity has features unique to itself, general mathematical models of the immune system may not be appropriate. The differential equations model that we propose is based on current knowledge of the biology of pulmonary innate immunity and accurately reproduces known features of the initial phase of the dynamics of pulmonary innate system as exhibited in recent experiments. Further, we propose to use the model as a starting point for interrogation with clinical data from a new noninvasive technique for sampling alveolar lining fluid.

Indexed as

Models, ImmunologicalAnimalsComputer SimulationImmunity, InnateLung DiseasesMice

Identifiers

PMID22233972
PMCPMC3272130

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.