ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2012
5-HTTLPR short allele, resilience, and successful aging in older adults.
Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Genetic Variants Associated With Resilience in Human and Animal Studies.Frontiers in psychiatry · 2022Pooled it
- A Re-evaluation of Candidate Gene Studies for Well-Being in Light of Genome-Wide Evidence.Journal of happiness studies · 2022Article
- Association between resilience and a functional polymorphism in the serotonin transporter (SLC6A4) gene: A meta-analysis.EXCLI journal · 2020Article
- Genotype, resilience and function and physical activity post hip fracture.International journal of orthopaedic and trauma nursing · 2019Article
- Neurobiological Mechanisms of Stress Resilience and Implications for the Aged Population.Current neuropharmacology · 2018Review
- Candidate SNP associations of optimism and resilience in older adults: exploratory study of 935 community-dwelling adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2014Article
- Connectivity underlying emotion conflict regulation in older adults with 5-HTTLPR short allele: a preliminary investigation.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2014Article
- Perceived stress is associated with subclinical cerebrovascular disease in older adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2014Article
- Serotonin transporter genotype and mild traumatic brain injury independently influence resilience and perception of limitations in veterans.Journal of psychiatric research · 2013Article
- Role of 5-HTTLPR polymorphism in the development of the inward/outward personality organization: a genetic association study.PloS one · 2013Article
- Association between Neurocognitive Impairment and the Short Allele of the 5-HTT Promoter Polymorphism in Depression: A Pilot Study.Psychiatry journal · 2013Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveResilience is proposed as a significant component of successful aging. Young adult carriers of the Serotonin Transporter Polymorphism (5-HTTLPR) short(s) allele appear to have reduced resilience to stress. We examined whether the presence of the short allele was associated with poorer emotional resilience in older adults.
methodsIn a cross-sectional study of 99 healthy, community-dwelling, older adults, we determined 5-HTTLPR genotype status and administered the Connor-Davidson Resilience Scale and self-reported measures of successful aging, cognition, and health.
resultsThere was no significant association between the 5-HTTLPR s allele and resilience. S allele carriers had worse cognition and self-report ratings of successful aging.
conclusionThese findings suggest that the impact of the 5-HTTLPR s allele on stress-related outcomes may attenuate with older age. However, s allele status appears to be a biomarker of poorer self-rated successful aging, and cognitive performance in older adults.
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Registered trials
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