Evidence map›Paper›PMID 22233676›Full record

ReviewNature reviews. Molecular cell biology2012

Dynamin, a membrane-remodelling GTPase.

Shawn M Ferguson, Pietro De Camilli

Abstract readReview
In one paragraph

Review in Nature reviews. Molecular cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 556 papers.

0numbers the graph read from it
0cells of the map it votes in
556citing papers in PubMed
36.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

556 citing papers in PubMed, 969 citations in OpenAlex.

  1. Visualization of membrane-stabilized SorCS2Journal of structural biology: X · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Borrowed scissors for lysosome fission.Nature cell biology · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. MX2 Mediates Collapse of the HIV-1 Capsid.bioRxiv : the preprint server for biology · 2026
    Article
  15. A local solution to local load: Myo1E as a tension-responsive actuator in clathrin-mediated endocytosis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  16. Review
  17. Article
  18. Article
  19. The contribution of endocytic mediators to itch transmission.bioRxiv : the preprint server for biology · 2026
    Article
  20. Article

496 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Shawn M FergusonDepartment of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA. shawn.ferguson@yale.edu
Pietro De Camilli
Howard Hughes Medical Institute · USYale University · US

Funding

Yale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI Richard A Flavell · 1993 to 2026
$44.0M
Yale/NIDA Neuroproteomics Research CenterP30DA018343 · NIDA · YALE UNIVERSITY · PI Marina R Picciotto · 2004 to 2026
$37.1M
Molecular Mechanisms in Synaptic Vesicle RecyclingR37NS036251 · NINDS · YALE UNIVERSITY · PI DE CAMILLI, PIETRO · 2010 to 2016
$2.7M
Howard Hughes Medical InstituteNIDA NIH HHS DA018343NIDA NIH HHS P30 DA018343NIDDK NIH HHS DK45735NIDDK NIH HHS P30 DK045735NINDS NIH HHS R37 NS036251NINDS NIH HHS R37NS036251
6 · The paper itself

Abstract

Dynamin, the founding member of a family of dynamin-like proteins (DLPs) implicated in membrane remodelling, has a critical role in endocytic membrane fission events. The use of complementary approaches, including live-cell imaging, cell-free studies, X-ray crystallography and genetic studies in mice, has greatly advanced our understanding of the mechanisms by which dynamin acts, its essential roles in cell physiology and the specific function of different dynamin isoforms. In addition, several connections between dynamin and human disease have also emerged, highlighting specific contributions of this GTPase to the physiology of different tissues.

Indexed as

AnimalsCell MembraneDynaminsEndocytosisGTP PhosphohydrolasesHumansIsoenzymesMammalsMembrane FluidityMiceModels, BiologicalModels, MolecularProtein ConformationDynaminsGTP PhosphohydrolasesIsoenzymes

Identifiers

PMID22233676
PMCPMC3519936
OpenAlexW1981431290

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.