ArticleNature communications2012
Rapid and adaptive evolution of MHC genes under parasite selection in experimental vertebrate populations.
Article in Nature communications, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers.
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Who cites it
131 citing papers in PubMed, 319 citations in OpenAlex.
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- Ancient DNA study provides clues to leprosy susceptibility in medieval Europe.Genome biology · 2026Article
- Adaptive radiation and structural tailoring of the VietnameseFrontiers in genetics · 2026Article
- Allelic diversity ofVeterinary and animal science · 2025Article
- Twenty years of tuberculosis-driven selection shaped the evolution of the meerkat major histocompatibility complex.Nature ecology & evolution · 2025Article
- Chromosome-level genome assembly of the coral grouper, Epinephelus corallicola and its evolutionary insights into Eupercaria.BMC genomics · 2025Article
- Increased heterozygosity and balancing selection in isofemale generations of Anopheles stephensi under laboratory conditions.BMC genomics · 2025Article
- Development of the Roe Deer-Pathogens (Basel, Switzerland) · 2025Article
- Balancing selection shapes population differentiation of major histocompatibility complex genes in wild golden snub-nosed monkeys.Current zoology · 2024Article
- DNA Methylation Carries Signatures of Sublethal Effects Under Thermal Stress in Loggerhead Sea Turtles.Evolutionary applications · 2024Article
- Major histocompatibility complex genes exhibit a potential immunological role in mixed Eimeria-infected broiler cecum analyzed using RNA sequencing.Animal bioscience · 2024Article
- Parasite-mediated predation determines infection in a complex predator-prey-parasite system.Proceedings. Biological sciences · 2024Article
- Only rare classical MHC-I alleles are highly expressed in the European house sparrow.Proceedings. Biological sciences · 2024Article
- Immunogenetic-pathogen networks shrink in Tome's spiny rat, a generalist rodent inhabiting disturbed landscapes.Communications biology · 2024Article
- Article
- How to Predict Binding Specificity and Ligands for New MHC-II Alleles with MixMHC2pred.Methods in molecular biology (Clifton, N.J.) · 2024Article
- HLA Genes: A Hallmark of Functional Genetic Variation and Complex Evolution.Methods in molecular biology (Clifton, N.J.) · 2024Review
- HLA Genetics for the Human Diseases.Advances in experimental medicine and biology · 2024Review
- Pathogenic selection promotes adaptive immune variations against serious bottlenecks in early invasions of bullfrogs.iScience · 2023Article
71 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genes of the major histocompatibility complex are the most polymorphic genes in vertebrates, with more than 1,000 alleles described in human populations. How this polymorphism is maintained, however, remains an evolutionary puzzle. Major histocompatibility complex genes have a crucial function in the adaptive immune system by presenting parasite-derived antigens to T lymphocytes. Because of this function, varying parasite-mediated selection has been proposed as a major evolutionary force for maintaining major histocompatibility complex polymorphism. A necessary prerequisite of such a balancing selection process is rapid major histocompatibility complex allele frequency shifts resulting from emerging selection by a specific parasite. Here we show in six experimental populations of sticklebacks, each exposed to one of two different parasites, that only those major histocompatibility complex alleles providing resistance to the respective specific parasite increased in frequency in the next host generation. This result demonstrates experimentally that varying parasite selection causes rapid adaptive evolutionary changes, thus facilitating the maintenance of major histocompatibility complex polymorphism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.