ArticleNature communications2012
Programmable multivalent display of receptor ligands using peptide nucleic acid nanoscaffolds.
Article in Nature communications, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 111 citations in OpenAlex.
- DNA-programmed bispecific peptide assemblies for delivering cytotoxic payload to cells expressing EGFR and MET receptors.RSC chemical biology · 2026Article
- Mechanism-Guided Nanoengineered Therapeutic Peptides for Bone Healing.International journal of nanomedicine · 2026Review
- Bispecific DNA-Peptide Probes for Targeting Receptor Pairs on Live Cells.Angewandte Chemie (International ed. in English) · 2025Article
- Functionalized tetrahedral DNA frameworks for the capture of circulating tumor cells.Nature protocols · 2024Review
- Visible Light-Induced Templated Metathesis of Peptide-Nucleic Acid Conjugates with a Diselenide Bridge.Biomolecules · 2023Article
- Rational multivalency construction enables bactericidal effect amplification and dynamic biomaterial design.Innovation (Cambridge (Mass.)) · 2023Article
- Perspectives on conformationally constrained peptide nucleic acid (PNA): insights into the structural design, properties and applications.RSC chemical biology · 2022Review
- Engineering mono- and multi-valent inhibitors on a modular scaffold.Chemical science · 2021Article
- Intrinsically cell-penetrating multivalent and multitargeting ligands for myotonic dystrophy type 1.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Instructing cells with programmable peptide DNA hybrids.Nature communications · 2017Article
- Suppression of Cocaine-Evoked Hyperactivity by Self-Adjuvanting and Multivalent Peptide Nanofiber Vaccines.ACS chemical neuroscience · 2016Article
- Design, preparation, and selection of DNA-encoded dynamic libraries.Chemical science · 2015Article
- Multivalent LKγ-PNA oligomers bind to a human telomere DNA G-rich sequence to form quadruplexes.Bioorganic & medicinal chemistry letters · 2015Article
- Lighting Up the Force: Investigating Mechanisms of Mechanotransduction Using Fluorescent Tension Probes.Molecular and cellular biology · 2015Review
- Green fluorescent protein nanopolygons as monodisperse supramolecular assemblies of functional proteins with defined valency.Nature communications · 2015Article
- PNA-Based Multivalent Scaffolds Activate the Dopamine D2 Receptor.ACS medicinal chemistry letters · 2015Article
- A dynamic combinatorial approach for identifying side groups that stabilize DNA-templated supramolecular self-assemblies.International journal of molecular sciences · 2015Article
- Recent advances in engineering polyvalent biological interactions.Biomacromolecules · 2015Review
- Synthesis and characterization of gadolinium-Peptidomimetic complex as an αvβ3 integrin targeted MR contrast agent.Bioorganic & medicinal chemistry letters · 2015Article
- DNA display of glycoconjugates to emulate oligomeric interactions of glycans.Beilstein journal of organic chemistry · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Multivalent effects dictate the binding affinity of multiple ligands on one molecular entity to receptors. Integrins are receptors that mediate cell attachment through multivalent binding to peptide sequences within the extracellular matrix, and overexpression promotes the metastasis of some cancers. Multivalent display of integrin antagonists enhances their efficacy, but current scaffolds have limited ranges and precision for the display of ligands. Here we present an approach to studying multivalent effects across wide ranges of ligand number, density, and three-dimensional arrangement. Using L-lysine γ-substituted peptide nucleic acids, the multivalent effects of an integrin antagonist were examined over a range of 1-45 ligands. The optimal construct improves the inhibitory activity of the antagonist by two orders of magnitude against the binding of melanoma cells to the extracellular matrix in both in vitro and in vivo models.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.