Evidence map›Paper›PMID 22233585›Full record

ReviewMalaria journal2012

Understanding the population genetics of Plasmodium vivax is essential for malaria control and elimination.

Alicia Arnott, Alyssa E Barry, John C Reeder

Open access · goldAbstract readReview
In one paragraph

Review in Malaria journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 139 citations in OpenAlex.

  1. Parasite epidemiology and control · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Population Dynamics ofMicroorganisms · 2025
    Article
  6. Article
  7. Review
  8. Genetic diversity of theParasite epidemiology and control · 2024
    Article
  9. Genetic Structure of IntroducedTropical medicine and infectious disease · 2024
    Article
  10. Review
  11. Article
  12. Procedure for Handling and Storage ofTropical medicine and infectious disease · 2023
    Article
  13. Distinct Allelic Diversity ofJournal of tropical medicine · 2023
    Article
  14. Retrospective analysis ofFrontiers in microbiology · 2023
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Pathogens (Basel, Switzerland) · 2021
    Article
  20. Temporal Changes in the Genetic Diversity ofPathogens (Basel, Switzerland) · 2021
    Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Alicia ArnottCentre for Population Health, Burnet Institute, Melbourne, Australia.
Alyssa E Barry
John C Reeder
Burnet Institute · AUWalter and Eliza Hall Institute of Medical Research · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traditionally, infection with Plasmodium vivax was thought to be benign and self-limiting, however, recent evidence has demonstrated that infection with P. vivax can also result in severe illness and death. Research into P. vivax has been relatively neglected and much remains unknown regarding the biology, pathogenesis and epidemiology of this parasite. One of the fundamental factors governing transmission and immunity is parasite diversity. An understanding of parasite population genetic structure is necessary to understand the epidemiology, diversity, distribution and dynamics of natural P. vivax populations. In addition, studying the population structure of genes under immune selection also enables investigation of the dynamic interplay between transmission and immunity, which is crucial for vaccine development. A lack of knowledge regarding the transmission and spread of P. vivax has been particularly highlighted in areas where malaria control and elimination programmes have made progress in reducing the burden of Plasmodium falciparum, yet P. vivax remains as a substantial obstacle. With malaria elimination back on the global agenda, mapping of global and local P. vivax population structure is essential prior to establishing goals for elimination and the roll-out of interventions. A detailed knowledge of the spatial distribution, transmission and clinical burden of P. vivax is required to act as a benchmark against which control targets can be set and measured. This paper presents an overview of what is known and what is yet to be fully understood regarding P. vivax population genetics, as well as the importance and application of P. vivax population genetics studies.

Indexed as

Genetics, PopulationGenetic VariationHumansMalaria, VivaxPlasmodium vivax

Identifiers

PMID22233585
PMCPMC3298510
OpenAlexW2116272678

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.