Trial reportPain medicine (Malden, Mass.)2012
Experimental pain ratings and reactivity of cortisol and soluble tumor necrosis factor-α receptor II following a trial of hypnosis: results of a randomized controlled pilot study.
Trial report in Pain medicine (Malden, Mass.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness of Stress-Reducing Interventions on the Response to Challenges to the Immune System: A Meta-Analytic Review.Psychotherapy and psychosomatics · 2019Pooled it
- Psychobiological response to pain in female adolescents with nonsuicidal self-injury.Journal of psychiatry & neuroscience : JPN · 2017Trial
- Autonomic nervous system and hypothalamic-pituitary-adrenal axis response to experimentally induced cold pain in adolescent non-suicidal self-injury--study protocol.BMC psychiatry · 2015Trial
- Computer-delivered social norm message increases pain tolerance.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2014Trial
- Opioid treatment of experimental pain activates nuclear factor-κB.Journal of opioid managementTrial
- Article
- "Close your eyes and relax": the role of hypnosis in reducing anxiety, and its implications for the prevention of cardiovascular diseases.Frontiers in psychology · 2024Review
- Resveratrol Inhibition of the WNT/β-Catenin Pathway following Discogenic Low Back Pain.International journal of molecular sciences · 2022Article
- Dietary Interventions for Treatment of Chronic Pain: Oxidative Stress and Inflammation.Pain and therapy · 2020Review
- Evaluation of Potential Pain Biomarkers in Saliva and Pain Perception After Corneal Advanced Surface Ablation Surgery.Clinical ophthalmology (Auckland, N.Z.) · 2020Article
- Determining the biological associates of acute cold pressor post-encoding stress effects on human memory: The role of salivary interleukin-1β.Brain, behavior, and immunity · 2019Article
- Examining the Impact of a Resilience-Based Hope Intervention on Pain-Evoked Cortisol Response.Journal of undergraduate research (Gainesville, Fla.) · 2018Article
- Age differences in salivary markers of inflammation in response to experimental pain: does venipuncture matter?Journal of pain research · 2017Article
- Reliability of Potential Pain Biomarkers in the Saliva of Healthy Subjects: Inter-Individual Differences and Intersession Variability.PloS one · 2016Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
objectiveCurrent evidence supports the efficacy of hypnosis for reducing the pain associated with experimental stimulation and various acute and chronic conditions; however, the mechanisms explaining how hypnosis exerts its effects remain less clear. The hypothalamic-pituitary-adrenal (HPA) axis and pro-inflammatory cytokines represent potential targets for investigation given their purported roles in the perpetuation of painful conditions; yet, no clinical trials have thus far examined the influence of hypnosis on these mechanisms.
designHealthy participants, highly susceptible to the effects of hypnosis, were randomized to either a hypnosis intervention or a no-intervention control. Using a cold pressor task, assessments of pain intensity and pain unpleasantness were collected prior to the intervention (Pre) and following the intervention (Post) along with pain-provoked changes in salivary cortisol and the soluble tumor necrosis factor-α receptor II (sTNFαRII).
resultsCompared with the no-intervention control, data analyses revealed that hypnosis significantly reduced pain intensity and pain unpleasantness. Hypnosis was not significantly associated with suppression of cortisol or sTNFαRII reactivity to acute pain from Pre to Post; however, the effect sizes for these associations were medium-sized.
conclusionsOverall, the findings from this randomized controlled pilot study support the importance of a future large-scale study on the effects of hypnosis for modulating pain-related changes of the HPA axis and pro-inflammatory cytokines.
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