ArticleFrontiers in behavioral neuroscience2011
Cellular correlates of enhanced anxiety caused by acute treatment with the selective serotonin reuptake inhibitor fluoxetine in rats.
Article in Frontiers in behavioral neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- The effect of SSRIs on unconditioned anxiety: a systematic review and meta-analysis of animal studies.Psychopharmacology · 2024Pooled it
- Mental health in the peri-hospital period of older patients: the roles of physical symptoms burden and sleep quality.Age and ageing · 2026Article
- Neural oscillations in the nucleus accumbens-dorsal hippocampal circuits and behavioral effects of acute fluoxetine administration during the Tail suspension test in mice.Experimental brain research · 2025Article
- Comparison of cannabidiol to citalopram in targeting fear memory in female mice.Journal of cannabis research · 2020Article
- Methoxetamine affects brain processing involved in emotional response in rats.British journal of pharmacology · 2017Article
- 5-HTThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Responses of Withdrawal Interneurons to Serotonin Applications in Naïve and Learned Snails Are Different.Frontiers in cellular neuroscience · 2017Article
- Pattern of distribution of serotonergic fibers to the amygdala and extended amygdala in the rat.The Journal of comparative neurology · 2017Article
- The role of 5-HT1A receptors in mediating acute negative effects of antidepressants: implications in pediatric depression.Translational psychiatry · 2015Article
- Serotonergic responses to stress are enhanced in the central amygdala and inhibited in the ventral hippocampus during amphetamine withdrawal.The European journal of neuroscience · 2014Article
- Pharmacology of serotonin and female sexual behavior.Pharmacology, biochemistry, and behavior · 2014Review
- Sex differences and estrous cycle in female rats interact with the effects of fluoxetine treatment on fear extinction.Behavioural brain research · 2013Article
- 5-HT2CR blockade in the amygdala conveys analgesic efficacy to SSRIs in a rat model of arthritis pain.Molecular pain · 2013Article
- Serotonergic innervation of the amygdala: targets, receptors, and implications for stress and anxiety.Histochemistry and cell biology · 2013Review
- Subacute fluoxetine enhances conditioned responding and conditioning-specific reflex modification of the rabbit nictitating membrane response: implications for drug treatment with selective serotonin reuptake inhibitors.Behavioural pharmacology · 2013Article
- A role for the extended amygdala in the fear-enhancing effects of acute selective serotonin reuptake inhibitor treatment.Translational psychiatry · 2013Article
- Factors influencing fluoxetine-induced sexual dysfunction in female rats.Behavioural brain research · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Selective serotonin reuptake inhibitors (SSRIs) are used extensively in the treatment of depression and anxiety disorders. The therapeutic benefits of SSRIs typically require several weeks of continuous treatment. Intriguingly, according to clinical reports, symptoms of anxiety may actually increase during the early stages of treatment although more prolonged treatment alleviates affective symptoms. Consistent with earlier studies that have used animal models to capture this paradoxical effect of SSRIs, we find that rats exhibit enhanced anxiety-like behavior on the elevated plus-maze 1 h after a single injection of the SSRI fluoxetine. Next we investigated the potential neural substrates underlying the acute anxiogenic effects by analyzing the morphological and physiological impact of acute fluoxetine treatment on principal neurons of the basolateral amygdala (BLA), a brain area that plays a pivotal role in fear and anxiety. Although earlier studies have shown that behavioral or genetic perturbations that are anxiogenic for rodents also increase dendritic spine density in the BLA, we find that a single injection of fluoxetine does not cause spinogenesis on proximal apical dendritic segments on BLA principal neurons an hour later. However, at the same time point when a single dose of fluoxetine caused enhanced anxiety, it also enhanced action potential firing in BLA neurons in ex vivo slices. Consistent with this finding, in vitro bath application of fluoxetine caused higher spiking frequency and this increase in excitability was correlated with an increase in the input resistance of these neurons. Our results suggest that enhanced excitability of amygdala neurons may contribute to the increase in anxiety-like behavior observed following acute fluoxetine treatment.
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