Evidence map›Paper›PMID 22232476›Full record

ReviewArchives of ophthalmology (Chicago, Ill. : 1960)2012

Dry eye disease: an immune-mediated ocular surface disorder.

William Stevenson, Sunil K Chauhan, Reza Dana

2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Archives of ophthalmology (Chicago, Ill. : 1960), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 313 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
313citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03074344 nacompletednot on this mapstarted 2016, after this paper: background citation

Study on the Effectiveness of Eye-drops Containing Cross-linked Hyaluronic Acid and Coenzyme Q10 in the Treatment of Patients With Mild to Moderate Dry Eye

TypeinterventionalSponsorAzienda Ospedaliera Universitaria Policlinico "G. Martino"Ran2016 to 2016Enrolled40ConditionsDry Eye SyndromeArmsXLHA+CoQ10, Hyaluronic acid (HA)
NCT03666884 phase4completednot on this mapstarted 2015, after this paper: background citation

The Comparison of 50 % Concentration Autologous Serum Eye Drops Versus Preservative Free Artificial Eye Drop Plus 0.05 % Cyclosporin Ophthalmic Emulsion in the Treatment of Severe Dry Eye Syndrome: A Randomized Comparative Study

TypeinterventionalSponsorSeref istekRan2015 to 2016Enrolled36ConditionsDry Eye SyndromeArmsCOE 2*1 (Restasis) + PFAT Refresh Single dose) 8*1, AS 50% eye drops 8*1
3 · Its place in the literature

Who cites it

313 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  7. Omega-3 and omega-6 polyunsaturated fatty acids for dry eye disease.The Cochrane database of systematic reviews · 2019
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253 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

William StevensonDepartment of Ophthalmology, Schepens Eye Research Institute and Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA.
Sunil K Chauhan
Reza Dana

Funding

Immunopathogenic Mechanisms of Dry Eye DiseaseR01EY020889 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI Reza Dana · 2010 to 2026
$7.9M
NEI NIH HHS EY20889NEI NIH HHS R01 EY020889
6 · The paper itself

Abstract

Dry eye disease is a multifactorial disorder of the tears and ocular surface characterized by symptoms of dryness and irritation. Although the pathogenesis of dry eye disease is not fully understood, it is recognized that inflammation has a prominent role in the development and propagation of this debilitating condition. Factors that adversely affect tear film stability and osmolarity can induce ocular surface damage and initiate an inflammatory cascade that generates innate and adaptive immune responses. These immunoinflammatory responses lead to further ocular surface damage and the development of a self-perpetuating inflammatory cycle. Herein, we review the fundamental links between inflammation and dry eye disease and discuss the clinical implications of inflammation in disease management.

Indexed as

Adaptive ImmunityAnimalsAntigen-Presenting CellsConjunctivaEpithelial CellsHumansImmunity, InnateInflammationKeratoconjunctivitis SiccaKiller Cells, NaturalLymphangiogenesisT-Lymphocytes, Regulatory

Identifiers

PMID22232476
PMCPMC3677724

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.