ArticleArchives of ophthalmology (Chicago, Ill. : 1960)2012
Multimodality diagnostic imaging in unilateral acute idiopathic maculopathy.
Article in Archives of ophthalmology (Chicago, Ill. : 1960), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 5 citations in OpenAlex.
- Multi modal imaging of pediatric unilateral macular discoid lesions.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Presumed bilateral acute idiopathic maculopathy in a pediatric patient.American journal of ophthalmology case reports · 2025Article
- Near-infrared imaging retinal diagnostic applications-a review.International ophthalmology · 2024Review
- Bilateral asynchronous acute idiopathic maculopathy with disease recurrence.American journal of ophthalmology case reports · 2024Article
- A case of acute idiopathic maculopathy in both eyes with peripheral vascular occlusion.BMC ophthalmology · 2024Article
- Global landscape of coxsackieviruses in human health.Virus research · 2024Review
- Acute-Onset Retinal Conditions Mimicking Acute Optic Neuritis: Overview and Differential Diagnosis.Journal of clinical medicine · 2023Review
- Acute idiopathic maculopathy after COVID-19 vaccination.American journal of ophthalmology case reports · 2022Article
- Classification of Non-Infectious and/or Immune Mediated Choroiditis: A Brief Overview of the Essentials.Diagnostics (Basel, Switzerland) · 2021Review
- Pseudomembranous conjunctivitis with hand, foot and mouth disease in a pregnant woman : a case report.BMC ophthalmology · 2021Article
- Choroidal Vascular Changes in Acute Idiopathic Maculopathy as Demonstrated by Multimodal Imaging including Optical Coherence Tomography Angiography.Case reports in ophthalmological medicine · 2021Article
- Incidental unilateral idiopathic maculopathy in children.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2020Article
- [Hand, foot and mouth disease-associated maculopathy: a 2-year course].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2020Article
- Long-term multimodal imaging in acute posterior multifocal placoid pigment epitheliopathy and association with coxsackievirus exposure.PloS one · 2020Article
- Unilateral acute idiopathic maculopathy secondary to yellow fever disease: a case report.American journal of ophthalmology case reports · 2019Article
- Acute unilateral maculopathy associated with adult onset of hand, foot and mouth disease: a case report.BMC ophthalmology · 2019Article
- A 24-year-old woman with sudden-onset, unilateral vision loss.Digital journal of ophthalmology : DJO · 2019Article
- Bilateral idiopathic retinal vasculitis following coxsackievirus A4 infection: a case report.BMC ophthalmology · 2017Article
- Multispectral fluorescence guided surgery; a feasibility study in a phantom using a clinical-grade laparoscopic camera system.American journal of nuclear medicine and molecular imaging · 2017Article
- Unilateral hemorrhagic maculopathy: An uncommon manifestation of hand, foot, and mouth disease.Indian journal of ophthalmology · 2016Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo describe the clinical features and imaging characteristics in unilateral acute idiopathic maculopathy.
methodsRetrospective review of 4 patients with a diagnosis of unilateral acute idiopathic maculopathy. Clinical characteristics (age, symptoms, Snellen visual acuity, and funduscopic features) and images from spectral-domain optical coherence tomography, fundus autofluorescence, fluorescein angiography, and indocyanine green angiography were analyzed.
resultsThe median (range) age at presentation was 31 (27-52) years. The median (range) interval between symptom onset and presentation was 4 (1-20) weeks. Associated systemic findings included a viral prodrome (50%), orchitis (50%), hand-foot-mouth disease (25%), and positive coxsackievirus titers (50%). The median (range) visual acuity at initial examination was 20/400 (20/70 to 1/400), which improved to 20/30 (20/20 to 20/60) at final follow-up. The median (range) follow-up time was 8 (8-13) weeks. Early in the disease course, the central macula developed irregular, circular areas of white-gray discoloration. Following recovery, the macula had a stippled retinal pigment epithelium characterized by rarefaction and hyperplasia. Fluorescein angiography demonstrated irregular early hyperfluorescence and late subretinal hyperfluorescence. Spectral-domain optical coherence tomography showed a partially reversible disruption of the outer photoreceptor layer. Fundus autofluorescence initially revealed stippled autofluorescence that eventually became more hypoautofluorescent. Indocyanine green angiography showed "moth-eaten"-appearing choroidal vasculature, suggestive of choroidal inflammation.
conclusionsThe imaging characteristics highlight the structural changes during the active and resolution phases of unilateral acute idiopathic maculopathy. The visual recovery correlates with structural changes and suggests that the pathogenesis involves inflammation of the inner choroid, retinal pigment epithelium, and outer photoreceptor complex that is partially reversible.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.