ArticleJournal of speech, language, and hearing research : JSLHR2012
The effect of tongue exercise on serotonergic input to the hypoglossal nucleus in young and old rats.
Article in Journal of speech, language, and hearing research : JSLHR, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Effect of sertraline on breathing in depressed patients without moderate-to-severe sleep-related breathing disorders.Sleep & breathing = Schlaf & Atmung · 2015Trial
- Review
- Ageing does not impair motor neuron adaptations: comparable motor unit responses to strength training in young and older adults.The Journal of physiology · 2026Article
- Task-Based Eating and Drinking Interventions in Animal Models: A Narrative Review of Functional Improvements and Neuromuscular Adaptations in Age-Related Dysphagia.Geriatrics (Basel, Switzerland) · 2024Review
- Vocal and tongue exercise in early to mid-stage Parkinson disease using the Pink1-/- rat.Brain research · 2024Article
- Tongue and laryngeal exercises improve tongue strength and vocal function outcomes in a Pink1-/- rat model of early Parkinson disease.Behavioural brain research · 2024Article
- Age-related sex differences in tongue strength and muscle morphometry in a rat model.Archives of oral biology · 2023Article
- Effects of Age and Lingual-Palatal Pressure Levels on Submental Surface Electromyography Measures.Dysphagia · 2023Article
- Pink1-/- Rats Demonstrate Swallowing and Gastrointestinal Dysfunction in a Model of Prodromal Parkinson Disease.Dysphagia · 2023Article
- Spinal motoneurons respond aberrantly to serotonin in a rabbit model of cerebral palsy.The Journal of physiology · 2023Article
- Dysphagia in Parkinson Disease: Part II-Current Treatment Options and Insights from Animal Research.Current physical medicine and rehabilitation reports · 2023Article
- Spinal motoneurons respond aberrantly to serotonin in a rabbit model of cerebral palsy.bioRxiv : the preprint server for biology · 2023Article
- Assays of tongue force, timing, and dynamics in rat and mouse models.Brain research bulletin · 2022Review
- A Strength Endurance Exercise Paradigm Mitigates Deficits in Hypoglossal-Tongue Axis Function, Strength, and Structure in a Rodent Model of Hypoglossal Motor Neuron Degeneration.Frontiers in neuroscience · 2022Article
- Increased tongue use enhances 5-HTRespiratory physiology & neurobiology · 2019Article
- Tongue Force Training Induces Plasticity of the Lingual Motor Cortex in Young Adult and Aged Rats.Frontiers in neuroscience · 2019Article
- Hypoglossal Motor Neuron Death Via Intralingual CTB-saporin (CTB-SAP) Injections Mimic Aspects of Amyotrophic Lateral Sclerosis (ALS) Related to Dysphagia.Neuroscience · 2018Article
- Differential impact of tongue exercise on intrinsic lingual muscles.The Laryngoscope · 2018Article
- Tongue Function: An Underrecognized Component in the Treatment of Obstructive Sleep Apnea with Mandibular Repositioning Appliance.Canadian respiratory journal · 2018Review
- Chronic Intermittent Hypoxia Induces the Long-Term Facilitation of Genioglossus Corticomotor Activity.Canadian respiratory journal · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
purposeBreathing and swallowing problems affect elderly people and may be related to age-associated tongue dysfunction. Hypoglossal motoneurons that innervate the tongue receive a robust, excitatory serotonergic (5HT) input and may be affected by aging. We used a rat model of aging and progressive resistance tongue exercise to determine whether age-related alterations in 5HT inputs to the hypoglossal nucleus can be modified. We hypothesized that tongue forces would increase with exercise, 5HT input to the tongue would decrease with age, and tongue exercise would augment 5HT input to the hypoglossal nucleus.
methodYoung (9-10 months), middle-aged (24-25 months), and old (32-33 months) male F344/BN rats received tongue exercise for 8 weeks. Immunoreactivity for 5HT was measured in digital images of sections through the hypoglossal nucleus using ImageJ software.
resultsTongue exercise resulted in increased maximum tongue forces at all ages. There was a statistically significant increase in 5HT immunoreactivity in the hypoglossal nucleus in exercised, young rats but only in the caudal third of the nucleus and primarily in the ventral half.
conclusionSpecificity found in serotonergic input following exercise may reflect the topographic organization of motoneurons in the hypoglossal nucleus and the tongue muscles engaged in the exercise paradigm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.