ReviewClinical microbiology reviews2012
Intruders below the radar: molecular pathogenesis of Bartonella spp.
Review in Clinical microbiology reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
146 citing papers in PubMed, 1 synthesis or guideline pooled it, 276 citations in OpenAlex.
- A systematic review on antibiotic therapy of cutaneous bacillary angiomatosis not related to major immunocompromising conditions: from pathogenesis to treatment.BMC infectious diseases · 2024Pooled it
- Postmortem evidence of Babesia and Bartonella infections in chronically ill suicidal young people.Parasites & vectors · 2026Article
- Bartonella transmission and gut microbiome dynamics in Ceratophyllus sciurorum fleas and their edible dormouse hosts (Glis glis).Parasites & vectors · 2026Article
- Drug target mining and in silico screening of Tibetan plant metabolites for potential alleviation of Oroya fever, a neglected tropical disease.Scientific reports · 2026Article
- Detection of intracellular bacteria in feline inflammatory cardiac, hepatic and renal diseases: a retrospective study using fluorescent in situ hybridisation.Journal of feline medicine and surgery · 2026Article
- Bartonella infection in small mammals and their ectoparasites from the Central Highlands of Madagascar: diversity and implication in future zoonotic surveillance.Parasites & vectors · 2026Article
- Manipulating vector transmission reveals local processes inParasitology · 2026Article
- Ectoparasite-borneParasitology · 2026Article
- A case of atypical cat scratch disease with bone and joint infection diagnosed through clinical metagenomics.IDCases · 2026Article
- Phlebotomine sand fly distribution, abundance and pathogen associations in Thailand: a scoping review.Parasitology · 2026Article
- Drug Design and Delivery for Intracellular Bacteria: Emerging Paradigms.Drug development research · 2025Review
- Article
- Porin A and α/β-hydrolase are necessary and sufficient for hemolysis induced by Bartonella bacilliformis.Nature communications · 2025Article
- The prevalence and genetic diversity of Bartonella species in wild rodents from South Korea.Scientific reports · 2025Article
- Uncovering the truth about cat-scratch disease.Open veterinary journal · 2025Review
- Experimental Infection of Ferrets withPathogens (Basel, Switzerland) · 2025Article
- Genetic diversity of Bartonella spp. in rodents and fleas from Poland.Scientific reports · 2025Article
- Neuroretinitis: a comprehensive review on aetiologies, clinical manifestations, and treatment options.Eye (London, England) · 2025Review
- Comparison of transcriptomic profiles between intracellular and extracellular Bartonella henselae.Communications biology · 2025Article
- Sneaky tactics: Ingenious immune evasion mechanisms ofVirulence · 2024Review
86 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bartonella spp. are facultative intracellular pathogens that employ a unique stealth infection strategy comprising immune evasion and modulation, intimate interaction with nucleated cells, and intraerythrocytic persistence. Infections with Bartonella are ubiquitous among mammals, and many species can infect humans either as their natural host or incidentally as zoonotic pathogens. Upon inoculation into a naive host, the bartonellae first colonize a primary niche that is widely accepted to involve the manipulation of nucleated host cells, e.g., in the microvasculature. Consistently, in vitro research showed that Bartonella harbors an ample arsenal of virulence factors to modulate the response of such cells, gain entrance, and establish an intracellular niche. Subsequently, the bacteria are seeded into the bloodstream where they invade erythrocytes and give rise to a typically asymptomatic intraerythrocytic bacteremia. While this course of infection is characteristic for natural hosts, zoonotic infections or the infection of immunocompromised patients may alter the path of Bartonella and result in considerable morbidity. In this review we compile current knowledge on the molecular processes underlying both the infection strategy and pathogenesis of Bartonella and discuss their connection to the clinical presentation of human patients, which ranges from minor complaints to life-threatening disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.