Evidence map›Paper›PMID 22232291›Full record

ArticleAntimicrobial agents and chemotherapy2012

Trimethoprim-sulfamethoxazole prophylaxis and antibiotic nonsusceptibility in invasive pneumococcal disease.

Heidi M Soeters, Anne von Gottberg, Cheryl Cohen, Vanessa Quan, Keith P Klugman

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Asplenia and spleen hypofunction.Nature reviews. Disease primers · 2022
    Review
  5. Serotypes and Vaccine Coverage ofPathogens (Basel, Switzerland) · 2020
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Heidi M SoetersDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA. hsoeters@email.unc.edu
Anne von Gottberg
Cheryl Cohen
Vanessa Quan
Keith P Klugman

Funding

PHS HHS U60/CCU022088
6 · The paper itself

Abstract

Among 5,043 invasive pneumococcal disease (IPD) isolates identified through South African national surveillance from 2003 to 2007, we estimated the effect of trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis on antimicrobial resistance. Patients on TMP-SMX prophylaxis were more likely to have a pneumococcal isolate nonsusceptible to TMP-SMX, penicillin, and rifampin. TMP-SMX nonsusceptibility was associated with nonsusceptibility to penicillin, erythromycin, and rifampin and multidrug resistance. This study informs empirical treatment of suspected IPD in patients with a history of TMP-SMX use.

Indexed as

Drug Resistance, Multiple, BacterialAdolescentAdultAgedAnti-Bacterial AgentsChildChild, PreschoolErythromycinFemaleHumansInfantInfant, NewbornLongitudinal StudiesMaleMiddle AgedPenicillinsAnti-Bacterial AgentsErythromycinPenicillinsRifampinTrimethoprim, Sulfamethoxazole Drug Combination

Identifiers

PMID22232291
PMCPMC3294938

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.