ReviewMethods in molecular biology (Clifton, N.J.)2012
New frontiers in animal research of psychiatric illness.
Review in Methods in molecular biology (Clifton, N.J.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 59 citations in OpenAlex.
- A New Three-Hit Mouse Model of Neurodevelopmental Disorder with Cognitive Impairments and Persistent Sociability Deficits.Brain sciences · 2024Article
- Developmental emergence of persistent memory for contextual and auditory fear in mice.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Child maltreatment and psychosis.Neurobiology of disease · 2019Review
- Enhancing the Utility of Preclinical Research in Neuropsychiatry Drug Development.Methods in molecular biology (Clifton, N.J.) · 2019Review
- An Overview of Animal Models Related to Schizophrenia.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2019Review
- Amygdala hyper-connectivity in a mouse model of unpredictable early life stress.Translational psychiatry · 2018Review
- Advances in nonhuman primate models of autism: Integrating neuroscience and behavior.Experimental neurology · 2018Review
- Rat animal models for screening medications to treat alcohol use disorders.Neuropharmacology · 2017Review
- Early Life Stress, Mood, and Anxiety Disorders.Chronic stress (Thousand Oaks, Calif.) · 2017Article
- Early life stress perturbs the maturation of microglia in the developing hippocampus.Brain, behavior, and immunity · 2016Article
- Rodent models in neuroscience research: is it a rat race?Disease models & mechanisms · 2016Review
- Article
- Modeling neurodevelopmental cognitive deficits in tasks with cross-species translational validity.Genes, brain, and behavior · 2016Review
- RDoC and translational perspectives on the genetics of trauma-related psychiatric disorders.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2016Review
- Animal models of gene-environment interaction in schizophrenia: A dimensional perspective.Progress in neurobiology · 2016Review
- PCP-based mice models of schizophrenia: differential behavioral, neurochemical and cellular effects of acute and subchronic treatments.Psychopharmacology · 2015Article
- Maternal Style Selectively Shapes Amygdalar Development and Social Behavior in Rats Genetically Prone to High Anxiety.Developmental neuroscience · 2015Article
- The rare DAT coding variant Val559 perturbs DA neuron function, changes behavior, and alters in vivo responses to psychostimulants.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Absence of BRINP1 in mice causes increase of hippocampal neurogenesis and behavioral alterations relevant to human psychiatric disorders.Molecular brain · 2014Article
- Early life stress inhibits expression of ribosomal RNA in the developing hippocampus.PloS one · 2014Article
Corrections and comments
- Erratum issuedKrystal, Uohn J [corrected to Krystal, John H]
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Alterations in neurodevelopment are thought to modify risk of numerous psychiatric disorders, including schizophrenia, autism, ADHD, mood and anxiety disorders, and substance abuse. However, little is known about the cellular and molecular changes that guide these neurodevelopmental changes and how they contribute to mental illness. In this review, we suggest that elucidating this process in humans requires the use of model organisms. Furthermore, we advocate that such translational work should focus on the role that genes and/or environmental factors play in the development of circuits that regulate specific physiological and behavioral outcomes in adulthood. This emphasis on circuit development, as a fundamental unit for understanding behavior, is distinct from current approaches of modeling psychiatric illnesses in animals in two important ways. First, it proposes to replace the diagnostic and statistical manual of mental disorders (DSM) diagnostic system with measurable endophenotypes as the basis for modeling human psychopathology in animals. We argue that a major difficulty in establishing valid animal models lies in their reliance on the DSM/International Classification of Diseases conceptual framework, and suggest that the Research Domain Criteria project, recently proposed by the NIMH, provides a more suitable system to model human psychopathology in animals. Second, this proposal emphasizes the developmental origin of many (though clearly not all) psychiatric illnesses, an issue that is often glossed over in current animal models of mental illness. We suggest that animal models are essential to elucidate the mechanisms by which neurodevelopmental changes program complex behavior in adulthood. A better understanding of this issue, in animals, is the key for defining human psychopathology, and the development of earlier and more effective interventions for mental illness.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.