ArticleCancer2012
When parents disclose BRCA1/2 test results: their communication and perceptions of offspring response.
Article in Cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Cascade Testing for Hereditary Cancer Syndromes: Should We Move Toward Direct Relative Contact? A Systematic Review and Meta-Analysis.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022Pooled it
- The psychological impact of genetic information on children: a systematic review.Genetics in medicine : official journal of the American College of Medical Genetics · 2016Pooled it
- A pilot randomized trial of an educational intervention to increase genetic counseling and genetic testing among Latina breast cancer survivors.Journal of genetic counseling · 2021Trial
- Knowledge and perceptions of familial and genetic risks for breast cancer risk in adolescent girls.Breast cancer research and treatment · 2012Trial
- Support for Disclosure of Hereditary Tumor Risk to Children and Adolescents: A Scoping Review.Japan journal of nursing science : JJNS · 2026Article
- Do people with hereditary cancer syndromes inform their at-risk relatives? A systematic review and meta-analysis.PEC innovation · 2023Article
- Parental Understanding of Their Child's Germline Genomic Testing: Intent of Disclosure to Their Child and Family.Journal of personalized medicine · 2023Article
- Family communication challenges of adolescents and young adults with Li-Fraumeni syndrome: Implications for psychosocial care.Patient education and counseling · 2022Article
- Long-Term Adaptation Among Adolescent and Young Adult Children to Familial Cancer Risk.Pediatrics · 2022Article
- Whether, when, and how to communicate genetic risk to minors: 'I wanted more information but I think they were scared I couldn't handle it'.Journal of genetic counseling · 2021Article
- The big reveal: Family disclosure patterns of BRCA genetic test results among young Black women with invasive breast cancer.Journal of genetic counseling · 2020Article
- Patients' views on variants of uncertain significance across indications.Journal of community genetics · 2020Review
- Assessing relatives' readiness for hereditary cancer cascade genetic testing.Genetics in medicine : official journal of the American College of Medical Genetics · 2020Article
- Family Communication Patterns and Challenges of Huntington's Disease Risk, the Decision to Pursue Presymptomatic Testing, and Test Results.Journal of Huntington's disease · 2020Article
- Preventative Health and Risk Behaviors Among Adolescent Girls With and Without Family Histories of Breast Cancer.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2019Article
- Talking with Children About Adult-Onset Hereditary Cancer Risk: A Developmental Approach for Parents.Journal of genetic counseling · 2018Article
- Decision making and experiences of young adults undergoing presymptomatic genetic testing for familial cancer: a longitudinal grounded theory study.European journal of human genetics : EJHG · 2018Article
- Supporting disclosure of genetic information to family members: professional practice and timelines in cancer genetics.Familial cancer · 2017Article
- Psychosocial and Clinical Factors Associated with Family Communication of Cancer Genetic Test Results among Women Diagnosed with Breast Cancer at a Young Age.Journal of genetic counseling · 2017Article
- Psychosocial Adjustment and Perceived Risk Among Adolescent Girls From Families With BRCA1/2 or Breast Cancer History.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2016Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundBRCA1/2 testing is not recommended for children, as risk reduction measures and screening are not generally recommended before 25 years old (YO). Little is known about the prevalence and predictors of parent communication to offspring and how offspring respond to this communication.
methodsSemi-structured interviews were conducted with parents who had BRCA1/2 testing and at least 1 child <25 YO. Logistic regressions were utilized to evaluate associations with communication. Framework analysis was utilized to analyze open-ended responses.
resultsA total of 253 parents completed interviews (61% response rate), reporting on 505 offspring. Twenty-nine percent of parents were BRCA1/2 mutation carriers. Three hundred thirty-four (66%) offspring learned of their parent's test result. Older offspring age (P ≤ .01), offspring gender (female, P = .05), parents' negative test result (P = .03), and parents' education (high school only, P = .02) were associated with communication to offspring. The most frequently reported initial offspring responses were neutral (41%) or relief (28%). Thirteen percent of offspring were reported to experience concern or distress (11%) in response to parental communication of their test results. Distress was more frequently perceived among offspring learning of their parent's BRCA1/2 positive or variant of uncertain significance result.
conclusionsMany parents communicate their BRCA1/2 test results to young offspring. Parents' perceptions of offspring responses appear to vary by offspring age and parent test result. A better understanding of how young offspring respond to information about hereditary risk for adult cancer could provide opportunities to optimize adaptive psychosocial responses to risk information and performance of health behaviors, in adolescence and throughout an at-risk life span.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.