ReviewJournal of molecular medicine (Berlin, Germany)2012
A new, powerful player in lipoprotein metabolism: brown adipose tissue.
Review in Journal of molecular medicine (Berlin, Germany), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 41 citations in OpenAlex.
- Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport.Nature communications · 2017Trial
- Adipo-oncology: adipocyte-derived factors govern engraftment, survival, and progression of metastatic cancers.Cell communication and signaling : CCS · 2024Review
- In-vivo detection of white adipose tissue browning: a multimodality imaging approach.Scientific reports · 2023Article
- Adipose Tissue Remodeling in Obesity: An Overview of the Actions of Thyroid Hormones and Their Derivatives.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Brown adipose TRX2 deficiency activates mtDNA-NLRP3 to impair thermogenesis and protect against diet-induced insulin resistance.The Journal of clinical investigation · 2022Article
- Effects of Gouda cheese andFood science & nutrition · 2021Article
- Obese Adipose Tissue Secretion Induces Inflammation in Preadipocytes: Role of Toll-Like Receptor-4.Nutrients · 2020Article
- Article
- Effect of Iodothyronines on Thermogenesis: Focus on Brown Adipose Tissue.Frontiers in endocrinology · 2018Review
- Quantification of Bone Fatty Acid Metabolism and Its Regulation by Adipocyte Lipoprotein Lipase.International journal of molecular sciences · 2017Article
- Differential Role of Adipose Tissues in Obesity and Related Metabolic and Vascular Complications.International journal of endocrinology · 2016Review
- Of mice and men: novel insights regarding constitutive and recruitable brown adipocytes.International journal of obesity supplements · 2015Review
- Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development.Nature communications · 2015Article
- CD36 is indispensable for thermogenesis under conditions of fasting and cold stress.Biochemical and biophysical research communications · 2015Article
- Brown Adipose Tissue Response Dynamics: In Vivo Insights with the Voltage Sensor 18F-Fluorobenzyl Triphenyl Phosphonium.PloS one · 2015Article
- 3,5-Diiodo-L-thyronine activates brown adipose tissue thermogenesis in hypothyroid rats.PloS one · 2015Article
- Mitochondrial uncoupling proteins and energy metabolism.Frontiers in physiology · 2015Review
- Genetic Dissection of Tissue-Specific Apolipoprotein E Function for Hypercholesterolemia and Diet-Induced Obesity.PloS one · 2015Article
- Syndecan-1 is required to maintain intradermal fat and prevent cold stress.PLoS genetics · 2014Article
- Brown fat fuel utilization and thermogenesis.Trends in endocrinology and metabolism: TEM · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Important causes for modern epidemics such as obesity, diabetes, and cardiovascular disease are over- and malnutrition. Dietary as well as endogenous lipids are transported through the bloodstream in lipoproteins, and disturbances in lipoprotein metabolism are associated with atherosclerosis, heart disease, and diabetes. Recent findings reveal biological principles-how lipoproteins, in particular triglyceride-rich lipoproteins, are metabolized and what factors regulate their processing. The fate of triglycerides delivered by lipoproteins is quite simple: either they can be stored or they can be utilized for combustion or biosynthetic pathways. In the healthy state, fatty acids derived from triglycerides can be burned in the heart, muscle, and other organs for actual work load, or they can be stored in white adipose tissue. The combination of storage and combustion is realized in brown adipose tissue (BAT), a peripheral organ that was long thought to be only of relevance in small mammals: Recent data however prove that BAT plays an important role in human adults. Here, we will review recent insights on how BAT controls triglyceride clearance and the possible implications for the treatment of chronic diseases caused by lipid mishandling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.