ArticleObesity surgery2012
Mapping of ghrelin gene expression and cell distribution in the stomach of morbidly obese patients--a possible guide for efficient sleeve gastrectomy construction.
Article in Obesity surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Gastric Fundus Ablation Plus Endoscopic Sleeve Gastroplasty for Weight Loss
Single-Stage Gastric Fundus Ablation and Endoscopic Sleeve Gastroplasty for Weight Loss
A Multi-site, Prospective Registry of Patients Undergoing Combined Gastric Mucosal Ablation With Endoscopic Sleeve Gastroplasty at True You Weight Loss
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- The impact of laparoscopic sleeve gastrectomy on plasma ghrelin levels: a systematic review.Obesity surgery · 2013Pooled it
- Clinical significance of ghrelin expression in the gastric mucosa of morbidly obese patients.World journal of surgery · 2013Trial
- Analysis of the Immunohistochemical Expression of Ghrelin in the Gastric Mucosa and Correlation with Weight Loss After Sleeve Gastrectomy.Obesity surgery · 2022Article
- Histopathologic findings on removed stomach after sleeve gastrectomy. Do they influence the outcome?Open medicine (Warsaw, Poland) · 2022Article
- Endoscopic Procedures for Weight Loss.Current obesity reports · 2021Review
- Weight loss with or without intragastric balloon causes divergent effects on ghrelin cell expression.Obesity science & practice · 2021Article
- Intragastric satiety-inducing device reduces food intake and suppresses body weight gain in a rodent model.Surgical endoscopy · 2021Article
- Gastric ghrelin cells in obese patients are hyperactive.International journal of obesity (2005) · 2021Article
- Quantitative and Topographic Analysis by Immunohistochemical Expression of Ghrelin Gastric Cells in Patients with Morbid Obesity.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Assessment of the Correlation Between Preoperative and Immediate Postoperative Gastric Volume and Weight Loss After Sleeve Gastrectomy Using Computed Tomography Volumetry.World journal of surgery · 2019Article
- Correlation Between the Number of Ghrelin-Secreting Cells in the Gastric Fundus and Excess Weight Loss after Sleeve Gastrectomy.Obesity surgery · 2019Article
- No Difference in Ghrelin-Producing Cell Expression in Obese Versus Non-obese Stomach: a Prospective Histopathological Case-Control Study.Obesity surgery · 2018Article
- Bariatric Arterial Embolization: Effect of Microsphere Size on the Suppression of Fundal Ghrelin Expression and Weight Change in a Swine Model.Radiology · 2018Article
- Comparison of Weight Loss, Ghrelin, and Leptin Hormones After Ligation of Left Gastric Artery and Sleeve Gastrectomy in a Rat Model.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Efficacy of laparoscopic sleeve gastrectomy for the treatment of obesity in a non-Western society.Eating and weight disorders : EWD · 2016Article
- Laparoscopic sleeve gastrectomy: More than a restrictive bariatric surgery procedure?World journal of gastroenterology · 2015Review
- Embolization of arterial gastric supply in obesity (EMBARGO): an endovascular approach in the management of morbid obesity. proof of the concept in the porcine model.Obesity surgery · 2015Article
- The role of bariatric surgery in the treatment of diabetes.Therapeutic advances in chronic disease · 2014Review
- Postoperative swallow study as a predictor of intermediate weight loss after sleeve gastrectomy.Obesity surgery · 2013Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGhrelin is secreted mainly in the stomach and plays a role in food intake regulation. Morbidly obese (MO) individuals report a decline in appetite after sleeve gastrectomy (SG), presumably due, in part, to ghrelin cell removal. Ghrelin cell distribution and expression were determined in three areas of resected stomach specimens from MO patients subjected to SG.
methodsResected stomach specimens from 20 MO patients undergoing SG were analyzed. Real-time polymerase chain reaction of ghrelin mRNA and immunohistostaining for ghrelin cells in three stomach regions (fundus, body, and pre-antral areas) were performed. Body mass index (BMI) and total plasma ghrelin levels were obtained before and 3 months postoperatively.
resultsGhrelin mRNA was detected throughout the stomach, its expression decreasing from the fundus towards the antrum. The relative quantification for ghrelin mRNA expression was 0.043, 0.026, and 0.015 at the fundus, body, and pre-antral region, respectively (P = 0.05, fundus vs. pre-antral region). Average ghrelin cell counts declined from 60 ± 40 to 45 ± 20 and 39 ± 13 cells/high power fields in the fundus, body, and pre-antral region, respectively. Three months after surgery, total plasma ghrelin levels decreased from 1,676 ± 470 to 1,179 ± 188 pg/ml (P < 0.00001) and BMI dropped from 46 ± 6 to 38 ± 5 kg/m2 (P < 0.00001).
conclusionsDistribution and expression of ghrelin-secreting cells throughout the stomach were defined, emphasizing the importance of meticulous resection of the fundus during SG for maximal ghrelin cell removal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.