ArticleStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2012
Radiotherapy with and without temozolomide in elderly patients with glioblastoma.
Article in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The role of radiation therapy in treatment of adults with newly diagnosed glioblastoma multiforme: a systematic review and evidence-based clinical practice guideline update.Journal of neuro-oncology · 2020Pooled it
- Management of elderly patients with glioblastoma-multiforme-a systematic review.The British journal of radiology · 2018Pooled it
- Radiotherapy plus concurrent or sequential temozolomide for glioblastoma in the elderly: a meta-analysis.PloS one · 2013Pooled it
- Review
- Article
- Temozolomide during radiotherapy of glioblastoma multiforme : Daily administration improves survival.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2017Article
- Radiation therapy for older patients with brain tumors.Radiation oncology (London, England) · 2017Review
- A prospective study on neurocognitive effects after primary radiotherapy in high-grade glioma patients.International journal of clinical oncology · 2016Article
- Radiotherapy of spinal cord gliomas : A retrospective mono-institutional analysis.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2016Article
- Radiotherapy with or without temozolomide in elderly patients aged ≥ 70 years with glioblastoma.Contemporary oncology (Poznan, Poland) · 2016Article
- Elderly patients with glioblastoma multiforme treated with concurrent temozolomide and standard- versus abbreviated-course radiotherapy.The Permanente journal · 2015Article
- Hippocampal EUD in primarily irradiated glioblastoma patients.Radiation oncology (London, England) · 2014Article
- Radiation therapy for older adults with glioblastoma: radical treatment, palliative treatment, or no treatment at all?Journal of neuro-oncology · 2014Review
- Irradiation facilitates the inhibitory effect of the heat shock protein 90 inhibitor NVP-BEP800 on the proliferation of malignant glioblastoma cells through attenuation of the upregulation of heat shock protein 70.Experimental and therapeutic medicine · 2014Article
- Temozolomide-induced liver damage. A case report.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2014Article
- Glioblastoma patients in Slovenia from 1997 to 2008.Radiology and oncology · 2014Article
- Analysis of equivalent uniform dose (EUD) and conventional radiation treatment parameters after primary and re-irradiation of malignant glioma.Radiation oncology (London, England) · 2013Article
- Personalized treatment strategies in glioblastoma: MGMT promoter methylation status.OncoTargets and therapy · 2013Review
- Short-course radiotherapy in elderly patients with glioblastoma: feasibility and efficacy of results from a single centre.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2013Article
- Radiochemotherapy and brachytherapy could be the standard treatment for anal canal cancer in elderly patients? A retrospective single-centre analysis.Medical oncology (Northwood, London, England) · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe optimal treatment for elderly patients (age ≥ 70 years) with glioblastoma (GBM) remains controversial. We conducted a retrospective analysis in 43 consecutive elderly patients with glioblastoma who either underwent radiotherapy (RT) or radiotherapy plus concomitant temozolomide (TMZ). PATIENTS AND
methodsA total of 43 patients (≥ 70 years of age, median age 75.8 years) with newly diagnosed glioblastoma and a Karnofsky performance status (KPS) ≥ 70 were treated with RT alone (median 60 Gy in 2 Gy single fractions) or RT plus TMZ at a dose of 75 mg/m(2) per day. The two groups were well-balanced; univariate (log-rank test) and multivariate Cox proportional hazards analysis were used to identify relevant prognostic factors.
resultsThe median overall survival (mOS) of the entire patient cohort was 264 days (8.8 months) and the median progression-free survival (PFS) was 192 days (6.4 months). The factors age, sex, previous surgery, KPS, and concomitant use of TMZ had no significant influence on OS/PFS; multivariate analysis was performed to obtain adjusted hazard ratios. TMZ use resulted in a trend toward poorer overall survival when applied concomitantly (314 days compared to 192 days within the TMZ group, p = 0.106). The subgroup analysis revealed that TMZ use resulted in significantly worse survival rates in patients with KPS70 (p = 0.027), but for patients with KPS80 this difference was not detectable.
conclusionTMZ should only be used carefully in elderly patients with unfavorable KPS. In this patient cohort, radiotherapy alone is a reasonable option. Standard RT plus concomitant TMZ may be an advantageous treatment option for elderly patients with newly diagnosed glioblastoma who present with good prognostic factors.
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