ArticlePediatric nephrology (Berlin, Germany)2012
The increasing incidence of initial steroid resistance in childhood nephrotic syndrome.
Article in Pediatric nephrology (Berlin, Germany), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Steroid treatment for the first episode of childhood nephrotic syndrome: comparison of the 8 and 12 weeks regimen using an individual patient data meta-analysis.European journal of pediatrics · 2021Pooled it
- Assessment of podocyte detachment as a pivotal step in the development of focal segmental glomerulosclerosis.Journal of the Egyptian National Cancer Institute · 2024Article
- Novel mutation patterns in children with steroid-resistant nephrotic syndrome.Clinical kidney journal · 2024Article
- Real-word adrenocorticotropic hormone treatment for childhood-onset nephrotic syndrome.Frontiers in pediatrics · 2023Article
- Article
- Association between HLA alleles and sub-phenotype of childhood steroid-sensitive nephrotic syndrome.World journal of pediatrics : WJP · 2022Article
- Nephrotic syndrome-associated hypercoagulopathy is alleviated by both pioglitazone and glucocorticoid which target two different nuclear receptors.Physiological reports · 2020Article
- Therapeutic Response to Corticosteroids Remains a Valid Approach to Initial Management of Children With Idiopathic Nephrotic Syndrome.Frontiers in pediatrics · 2020Article
- Children with Steroid-Resistant Nephrotic Syndrome: A Single -Center Experience.Materia socio-medica · 2018Article
- Histone deacetylase-2 expression and activity in children with nephrotic syndrome with different glucocorticoid response.Pediatric nephrology (Berlin, Germany) · 2018Article
- Exploring the Clinical and Genetic Spectrum of Steroid Resistant Nephrotic Syndrome: The PodoNet Registry.Frontiers in pediatrics · 2018Review
- Renal Tubular Complement 3 Deposition in Children with Primary Nephrotic Syndrome.BioMed research international · 2018Article
- Analysis of the genes responsible for steroid-resistant nephrotic syndrome and/or focal segmental glomerulosclerosis in Japanese patients by whole-exome sequencing analysis.Journal of human genetics · 2016Article
- Immunosuppressive therapy in children with steroid-resistant, frequently-relapsing, and steroid-dependent idiopathic nephrotic syndrome: a single center experience.Electronic physician · 2016Article
- Ethnic Differences in Childhood Nephrotic Syndrome.Frontiers in pediatrics · 2016Review
- A predictive model of progressive chronic kidney disease in idiopathic nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2015Article
- Spectrum of steroid-resistant and congenital nephrotic syndrome in children: the PodoNet registry cohort.Clinical journal of the American Society of Nephrology : CJASN · 2015Article
- Long-Term Outcomes in Children with Steroid-Resistant Nephrotic Syndrome Treated with Calcineurin Inhibitors.Frontiers in pediatrics · 2015Article
- Pathological profile of biopsied Egyptian children with primary nephrotic syndrome: 15-year single center experience.Journal of nephrology · 2014Article
- High Steroid Sensitivity among Children with Nephrotic Syndrome in Southwestern Nigeria.International journal of nephrology · 2014Article
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Authors and funding
2 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundRecently, a number of reports have highlighted changes in the histopathology and response to corticosteroid treatment in childhood nephrotic syndrome; however, these involved ethnically mixed populations. For comparison, the purpose of our research was to search for changes in the characteristics of nephrotic syndrome in a homogeneous population of Caucasian children over two consecutive decades.
methodsChart analysis was performed to identify children with new-onset nephrotic syndrome. The children were admitted to the Division of Pediatric Nephrology, Zabrze, during two periods: 1986-1995 (76 patients) and 1996-2005 (102 patients). Specifically, a comparison of clinical characteristics and morphology of nephrotic syndrome between the two groups was performed. Steroid resistance was defined as no remission within 8 weeks of corticosteroid treatment. Histopathology was available in 36.8% and 43.1% of patients respectively.
resultsThere was a significant increase in primary steroid resistance in the latter decade: 15.8% vs 31.4% (P = 0.017). Changes in the histopathology did not reach the level of statistical significance: minimal change nephrotic syndrome 25% vs 9% (P = 0.095), mesangial proliferative glomerulonephritis 46.4% vs 61.3% (P = 0.21), focal segmental glomerulosclerosis 17.9% vs 20.4% (P = 0.78), membranoproliferative glomerulonephritis 7.1% vs 6.8% (P = 1.0), membranous glomerulonephritis 3.6% vs 0% (P = 0.39).
conclusionsOur results show the increasing incidence of primary steroid resistance in childhood nephrotic syndrome.
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